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Literature summary extracted from

  • Herkert, N.M.; Freude, G.; Kunz, U.; Thiermann, H.; Worek, F.
    Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase (2012), Toxicol. Lett., 209, 173-178.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.7 HI-6 reactivates the sarin- and paraoxon-inhibited enzyme Cavia porcellus
3.1.1.7 HI-6 reactivates the sarin- and paraoxon-inhibited enzyme Homo sapiens
3.1.1.7 HI-6 reactivates the sarin- and paraoxon-inhibited enzyme Sus scrofa
3.1.1.7 obidoxime reactivates the sarin- and paraoxon-inhibited enzyme Cavia porcellus
3.1.1.7 obidoxime reactivates the sarin- and paraoxon-inhibited enzyme Homo sapiens
3.1.1.7 obidoxime reactivates the sarin- and paraoxon-inhibited enzyme Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 paraoxon more than 95% inhibition at 0.001 mM Cavia porcellus
3.1.1.7 paraoxon more than 95% inhibition at 0.001 mM Homo sapiens
3.1.1.7 paraoxon more than 95% inhibition at 0.001 mM Sus scrofa
3.1.1.7 sarin more than 95% inhibition at 50 nM Cavia porcellus
3.1.1.7 sarin more than 95% inhibition at 30 nM Homo sapiens
3.1.1.7 sarin more than 95% inhibition at 50 nM Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.0923
-
 acetylthiocholine enzyme from erythrocyte, pH and temperature not specified in the publication Homo sapiens
3.1.1.7 0.0924
-
 acetylthiocholine enzyme from muscle, pH and temperature not specified in the publication Homo sapiens
3.1.1.7 0.1011
-
 acetylthiocholine enzyme from brain, pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Cavia porcellus
-
 choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O Homo sapiens
-
 choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O Sus scrofa
-
 choline + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Cavia porcellus
-
-
-
3.1.1.7 Homo sapiens
-
-
-
3.1.1.7 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 brain
-
 Cavia porcellus
-
3.1.1.7 brain
-
 Homo sapiens
-
3.1.1.7 brain
-
 Sus scrofa
-
3.1.1.7 erythrocyte
-
 Cavia porcellus
-
3.1.1.7 erythrocyte
-
 Homo sapiens
-
3.1.1.7 erythrocyte
-
 Sus scrofa
-
3.1.1.7 muscle
-
 Cavia porcellus
-
3.1.1.7 muscle
-
 Homo sapiens
-
3.1.1.7 muscle
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Cavia porcellus choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O
-
 Sus scrofa choline + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Cavia porcellus thiocholine + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Sus scrofa thiocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Cavia porcellus
3.1.1.7 AChE
-
 Homo sapiens
3.1.1.7 AChE
-
 Sus scrofa