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Literature summary extracted from

  • Calligari, P.A.; Salgado, G.F.; Pelupessy, P.; Lopes, P.; Ouazzani, J.; Bodenhausen, G.; Abergel, D.
    Insights into internal dynamics of 6-phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics (2012), Proteins, 80, 1196-1210.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.31 drug development the enzyme is a target for anti-parasite drug development Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.31 glycosome
-
 Trypanosoma brucei 20015
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O Trypanosoma brucei
-
 6-phospho-D-gluconate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.31 Trypanosoma brucei
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.31 6-phospho-D-glucono-1,5-lactone + H2O
-
 Trypanosoma brucei 6-phospho-D-gluconate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.31 6PGL
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
3.1.1.31 metabolism the enzyme is one of the six enzymes of the pentose phosphate pathway of Trypanosoma brucei and hydrolyzes D-6-phosphogluconolactone to 6-phosphogluconic acid Trypanosoma brucei
3.1.1.31 additional information analysis of effects of ligand binding on the internal dynamics of the enzyme by molecular dynamics simulations and nuclear magnetic resonance, alterations of conformational exchange, overview. Residues R77 and R200, located near the active site, interact directly with the phosphate group of 6-phospho-D-gluconate. Residue H165 is actively involved in catalysis Trypanosoma brucei
3.1.1.31 physiological function the enzyme plays a key role during infection, by providing the important reductive agent NADPH, and forms ribose 5-phosphate, a major nucleic acid precursor, as well as several metabolic intermediates, such as fructose 6-phosphate and glyceraldehyde 3-phosphate Trypanosoma brucei