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Literature summary extracted from

  • Bhattacharyya, S.; Saha, S.; Giri, K.; Lanza, I.R.; Nair, K.S.; Jennings, N.B.; Rodriguez-Aguayo, C.; Lopez-Berestein, G.; Basal, E.; Weaver, A.L.; Visscher, D.W.; Cliby, W.; Sood, A.K.; Bhattacharya, R.; Mukherjee, P.
    Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance (2013), PLoS ONE, 8, e79167.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.22 L-serine + L-homocysteine Homo sapiens
-
 L-cystathionine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.22 A-2780 cell
-
 Homo sapiens
-
4.2.1.22 A-2780/CP-70 cell
-
 Homo sapiens
-
4.2.1.22 epithelial ovarian cancer cell
-
 Homo sapiens
-
4.2.1.22 OV-202 cell
-
 Homo sapiens
-
4.2.1.22 ovarian carcinoma cell
-
 Homo sapiens
-
4.2.1.22 SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.22 CBS
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.2.1.22 Homo sapiens the enzyme is overexpressed in primary epithelial ovarian cancer and ovarian cancer cell lines up

General Information

EC Number General Information Comment Organism
4.2.1.22 physiological function cystathionine beta-synthase contributes to advanced ovarian cancer progression and drug resistance. The enzyme also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial reactive oxygen species production, oxygen consumption and ATP generation Homo sapiens