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Literature summary extracted from

  • Han, J.Y.; Wang, H.Y.; Choi, Y.E.
    Production of dammarenediol-II triterpene in a cell suspension culture of transgenic tobacco (2014), Plant Cell Rep., 33, 225-233.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.125 synthesis the production of dammarenediol-II in a cell suspension culture of transgenic tobacco can be applied to the large-scale production of this compound and utilized as a source of pharmacologically active medicinal materials Panax ginseng

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.125 recombinant expression in Nicotiana tabacum cv. Xanthi leaves using transfection via Agrobacterium tumefaciens strain LBA4404, accumulation of dammarenediol-II in transgenic tobacco plants occurred in an organ-specific manner in descending order: roots, stems, leaves, flower buds, and transgenic cell suspension line 14 exhibits a high amount, overview Panax ginseng

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.125 (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O Panax ginseng
-
 dammarenediol II
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.125 Panax ginseng Q08IT1 gene PgDDS1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.125 root
-
 Panax ginseng
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.125 (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
-
 Panax ginseng dammarenediol II
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.125 dammarenediol-II synthase
-
 Panax ginseng
4.2.1.125 PgDDS1
-
 Panax ginseng

Expression

EC Number Organism Comment Expression
4.2.1.125 Panax ginseng induction by methyl jasmonate, overview up

General Information

EC Number General Information Comment Organism
4.2.1.125 metabolism the enzyme catalyzes the first step in the biosynthetic pathway for ginsenosides in Panax ginseng, overview Panax ginseng
4.2.1.125 physiological function dammarenediol-II synthase catalyzes the cyclization of 2,3-oxidosqualene to dammarenediol-II, which is the basic triterpene skeleton in dammarene-type saponin (ginsenosides) in Panax ginseng. Dammarenediol-II is present in the roots of Panax ginseng in trace amounts because it is an intermediate product in triterpene biosynthesis Panax ginseng