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Literature summary extracted from

  • Bruintjes, J.J.; Henning, R.H.; Douwenga, W.; van der Zee, E.A.
    Hippocampal cystathionine beta synthase in young and aged mice (2014), Neurosci. Lett., 563, 135-139.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.22 68000
-
 x * 68000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.22 L-serine + L-homocysteine Mus musculus
-
 L-cystathionine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.22 hippocampus
-
 Mus musculus
-
4.2.1.22 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-serine + L-homocysteine
-
 Mus musculus L-cystathionine + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.22 ? x * 68000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
4.2.1.22 CBS
-
 Mus musculus
4.2.1.22 cystathionine beta synthase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
4.2.1.22 Mus musculus mice at the unusual age of 28 months even have a higher hippocampal enzyme expression than young mice up

General Information

EC Number General Information Comment Organism
4.2.1.22 physiological function Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. The CBS/H2S pathway plays an important role in the protection of learning and memory functions in the brain at the level of the hippocampus Mus musculus