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Literature summary extracted from

  • Guggisberg, A.M.; Park, J.; Edwards, R.L.; Kelly, M.L.; Hodge, D.M.; Tolia, N.H.; Odom, A.R.
    A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites (2014), Nat. Commun., 5, 4467.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.23 expressed in Escherichia coli BL21(DE3)pLysS cells Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.3.23 hanging drop vapor diffusion method, using 0.1M HEPES (pH 7.5) and 20-25% (w/v) PEG 8000 Plasmodium falciparum

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.23 N70S the mutant shows wild type activity Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.23 cytoplasm
-
Plasmodium falciparum 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.23 Mg2+ contains Mg2+ in the active site Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.23 33000
-
x * 33000, SDS-PAGE Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.23 D-fructose 1-phosphate + H2O Plasmodium falciparum best substrate D-fructose + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.23 Plasmodium falciparum Q8IJ74
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.23 nickel agarose bead chromatography and Superdex 200 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.23 4-nitrophenyl phosphate + H2O
-
Plasmodium falciparum 4-nitrophenol + phosphate
-
?
3.1.3.23 D-erythrose 4-phosphate + H2O
-
Plasmodium falciparum D-erythrose + phosphate
-
?
3.1.3.23 D-fructose 1-phosphate + H2O best substrate Plasmodium falciparum D-fructose + phosphate
-
?
3.1.3.23 D-fructose 6-phosphate + H2O
-
Plasmodium falciparum D-fructose + phosphate
-
?
3.1.3.23 D-glucose 1-phosphate + H2O
-
Plasmodium falciparum D-glucose + phosphate
-
?
3.1.3.23 D-glucose 2-phosphate + H2O second best substrate Plasmodium falciparum D-glucose + phosphate
-
?
3.1.3.23 D-glucose 6-phosphate + H2O
-
Plasmodium falciparum D-glucose + phosphate
-
?
3.1.3.23 D-mannose 6-phosphate + H2O
-
Plasmodium falciparum D-mannose + phosphate
-
?
3.1.3.23 D-ribose 5-phosphate + H2O
-
Plasmodium falciparum D-ribose + phosphate
-
?
3.1.3.23 D-ribulose 5-phosphate + H2O
-
Plasmodium falciparum D-ribulose + phosphate
-
?
3.1.3.23 deoxyribose 5-phosphate + H2O
-
Plasmodium falciparum deoxyribose + phosphate
-
?
3.1.3.23 deoxyxylulose 5-phosphate + H2O
-
Plasmodium falciparum deoxyxylulose + phosphate
-
?
3.1.3.23 dihydroxyacetone phosphate + H2O
-
Plasmodium falciparum dihydroxyacetone + phosphate
-
?
3.1.3.23 methylerythritol phosphate + H2O
-
Plasmodium falciparum methylerythritol + phosphate
-
?
3.1.3.23 additional information low activity towards D-fructose 1,6-bisphosphate, D-galactose 1-phosphate, glycerol 2-phosphate, glucosamine 1-phosphate, D-mannose 1-phosphate, phosphoenolpyruvate, sedoheptulose 7-phosphate, sorbitol 6-phosphate, trehalose 6-phosphate, 2-phosphoglyceric acid, and 3-phosphoglyceric acid Plasmodium falciparum ?
-
?
3.1.3.23 additional information the enzyme is most active against monophosphorylated three to six-carbon monosaccharides Plasmodium falciparum ?
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.23 ? x * 33000, SDS-PAGE Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
3.1.3.23 HAD1
-
Plasmodium falciparum
3.1.3.23 haloacid dehalogenase-like sugar phosphatase
-
Plasmodium falciparum
3.1.3.23 PF3D7 1033400 locus name Plasmodium falciparum
3.1.3.23 sugar phosphatase
-
Plasmodium falciparum

General Information

EC Number General Information Comment Organism
3.1.3.23 malfunction loss of HAD1 is required for fosmidomycin resistance. Parasites lacking HAD1 have increased methylerythritol phosphate pathway metabolites, particularly the deoxyxylulose 5-phosphate reductoisomerase substrate deoxyxylulose 5-phosphate Plasmodium falciparum
3.1.3.23 metabolism HAD1 controls substrate availability to the methylerythritol phosphate pathway Plasmodium falciparum