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Literature summary extracted from

  • Casabon, I.; Crowe, A.M.; Liu, J.; Eltis, L.D.
    FadD3 is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria (2013), Mol. Microbiol., 87, 269-283.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.41 expressed in Escherichia coli Rosetta(DE3)pLysS cells Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.41 additional information neither 1beta(2'-propanoate)-3aalpha-H-4a(3''-propanoate)-7alphabeta-methylhexahydro-5-indanone nor 3aalpha-H-4aalpha(3'-propanoic acid)-5alpha-hydroxy-7alphabeta-methylhexahydro-1-indanone-D-lactone significantly inhibit enzyme activity Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.41 0.0098
-
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate at pH 7.3 and 22°C Mycobacterium tuberculosis
6.2.1.41 0.11
-
CoA at pH 7.3 and 22°C Mycobacterium tuberculosis
6.2.1.41 3
-
3aalpha-H-4a(3'-propanoate)-5alpha-hydroxy-7alphabeta-methylhexahydro-1-indanone at pH 7.3 and 22°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.41 ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA Mycobacterium tuberculosis
-
AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.41 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.41 Ni-Sepharose 6 column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.41 ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA
-
Mycobacterium tuberculosis AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
-
?
6.2.1.41 ATP + 3aalpha-H-4a(3'-propanoate)-5alpha-hydroxy-7alphabeta-methylhexahydro-1-indanone
-
Mycobacterium tuberculosis ?
-
?
6.2.1.41 additional information no activity with 3aalpha-H-4a(3'-propanoate)-5alpha-hydroxy-7alphabeta-methylhexahydro-1-indanone-D-lactone, 3-oxo-23,24-bisnorchol-4-en-22-oate, cholate, and 3beta-hydroxy-5-cholesten-26-oate Mycobacterium tuberculosis ?
-
?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.41 fadD3
-
Mycobacterium tuberculosis
6.2.1.41 HIP-CoA ligase
-
Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.2.1.41 7.1
-
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate at pH 7.3 and 22°C Mycobacterium tuberculosis
6.2.1.41 7.5
-
CoA at pH 7.3 and 22°C Mycobacterium tuberculosis
6.2.1.41 13
-
3aalpha-H-4a(3'-propanoate)-5alpha-hydroxy-7alphabeta-methylhexahydro-1-indanone at pH 7.3 and 22°C Mycobacterium tuberculosis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
6.2.1.41 4.4
-
3aalpha-H-4a(3'-propanoate)-5alpha-hydroxy-7alphabeta-methylhexahydro-1-indanone at pH 7.3 and 22°C Mycobacterium tuberculosis
6.2.1.41 66
-
CoA at pH 7.3 and 22°C Mycobacterium tuberculosis
6.2.1.41 730
-
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate at pH 7.3 and 22°C Mycobacterium tuberculosis