Literature summary extracted from

Peng, C.; Lu, Z.; Xie, Z.; Cheng, Z.; Chen, Y.; Tan, M.; Luo, H.; Zhang, Y.; He, W.; Yang, K.; Zwaans, B.M.; Tishkoff, D.; Ho, L.; Lombard, D.; He, T.C.; Dai, J.; Verdin, E.; Ye, Y.; Zhao, Y.
The first identification of lysine malonylation substrates and its regulatory enzyme (2011), Mol. Cell. Proteomics, 10, M111.012658.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.B43	nicotinamide	inhibits demalonylation and desuccinylation activity	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.1.B43	NAD+ + [protein]-N6-malonyl-L-lysine	Mus musculus	-	nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + [protein]-N6-succinyl-L-lysine	Mus musculus	-	nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.B43	Mus musculus	Q8K2C6	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.B43	additional information	Sirt5 shows negligible activity toward lysine deacetylation	Mus musculus	?	-	?
2.3.1.B43	NAD+ + AFNQG(N6-malonyl)KIFK	-	Mus musculus	nicotinamide + AFNQGKIFK + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + AYVDDTPAEQM(N6-malonyl)KAER	-	Mus musculus	nicotinamide + AYVDDTPAEQMKAER + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + DSYVGDEAQSDSYVGDEAQS(N6-malonyl)KR	-	Mus musculus	nicotinamide + DSYVGDEAQSDSYVGDEAQSKR + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + ETGVDLT(N6-succinyl)KDNMALQR	-	Mus musculus	nicotinamide + ETGVDLTKDNMALQR + 2'-O-succinyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + IEEELGS(N6-malonyl)KAK	-	Mus musculus	nicotinamide + IEEELGSKAK + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + SQG(N6-succinyl)KVLQATVV	-	Mus musculus	nicotinamide + SQGKVLQATVV + 2'-O-succinyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + TAIG(N6-malonyl)KAGYTDK	-	Mus musculus	nicotinamide + TAIGKAGYTDK + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + VLLPEYGGT(N6-succinyl)KVVLDDK	-	Mus musculus	nicotinamide + VLLPEYGGTKVVLDDK + 2'-O-succinyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + [protein]-N6-malonyl-L-lysine	-	Mus musculus	nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose	-	?
2.3.1.B43	NAD+ + [protein]-N6-succinyl-L-lysine	-	Mus musculus	nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.B43	SIRT5	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)