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Literature summary extracted from

  • Miller, M.E.; Adhikary, S.; Kolokoltsov, A.A.; Davey, R.A.
    Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection (2012), J. Virol., 86, 7473-7483.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.12 drug development acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus,the enzym eis a target for drug development Homo sapiens
3.1.4.12 medicine acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus, inhibition of the enzyme might be a threpeutic way Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 amitriptyline specific inhibitor Homo sapiens
3.1.4.12 desipramine specific inhibitor Homo sapiens
3.1.4.12 imipramine specific inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 endosome
-
 Homo sapiens 5768
-
3.1.4.12 lysosome
-
 Homo sapiens 5764
-
3.1.4.12 plasma membrane membrane damage or the interaction with some bacterial and viral pathogens can trigger the enzyme's recruitment to the plasma membrane Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O Homo sapiens
-
 a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 HEK-293 cell
-
 Homo sapiens
-
3.1.4.12 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O
-
 Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Homo sapiens
3.1.4.12 aSMase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 additional information
-
 acidic pH optimum Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.12 malfunction acid sphingomelin-specific drugs and multiple small interfering RNAs strongly inhibit the infection by ebolavirus and ebolavirus glycoprotein pseudotyped viruses but not by the pseudotypes bearing the glycoprotein of vesicular stomatitis virus, overview. ASMase siRNA-treated cells resist EBOV infection Homo sapiens
3.1.4.12 physiological function rhinovirus and measles virus each require the enzyme activity during early stages of infection, as well as the ebolavirus. Both sphingomyelin and ceramide are important components of lipid rafts and are potent signaling molecules. Each plays roles in mediating macropinocytosis, which has been shown to be important for ebolavirus infection. The binding of virus-like particles to cells is strongly associated with surface-localized ASMase as well as sphingomyelin-enriched sites, overview Homo sapiens