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Literature summary extracted from

  • Oguro, A.; Imaoka, S.
    Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase (2012), J. Lipid Res., 53, 505-512.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.106 Triton X-100 about 60% stimulation, optimum activity at 0.02% Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.106
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.106 D9A mutant is inactive towards lysophosphatidic acids Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.106 1-palmitoyl-2-lyso-sn-glycerol 3-phosphate 40 microM, about 50% inhibition Homo sapiens
3.1.3.106 lauric acid 40 microM, about 60% inhibition Homo sapiens
3.1.3.106 lysophosphatidylcholine
-
 Homo sapiens
3.1.3.106 additional information not inhibitory: 1-palmitoyl-sn-glycerol, 1-hexadecanol Homo sapiens
3.1.3.106 palmitic acid 40 microM, about 80% inhibition Homo sapiens
3.1.3.106 stearic acid about 20% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.106 0.003
-
 1-palmitoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens
3.1.3.106 0.0059
-
 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens
3.1.3.106 0.0062
-
 1-oleoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens
3.1.3.106 0.0064
-
 1-stearoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.106 Mg2+ in absence of Mg2+ activity towards 1-stearoyl-2-lyso-sn-glycerol 3-phosphate acid is significantly decreased Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.106 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.106 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-arachidonoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-oleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-palmitoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-palmitoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-stearoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-stearoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 additional information no substrates: dipalmitoyl phosphatidic acid, distearoyl phosphatidic acid Homo sapiens ?
-
 ?