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Literature summary extracted from

  • Tsutakawa, S.E.; Shin, D.S.; Mol, C.D.; Izumi, T.; Arvai, A.S.; Mantha, A.K.; Szczesny, B.; Ivanov, I.N.; Hosfield, D.J.; Maiti, B.; Pique, M.E.; Frankel, K.A.; Hitomi, K.; Cunningham, R.P.; Mitra, S.; Tainer, J.A.
    Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes (2013), J. Biol. Chem., 288, 8445-8455.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.21.2 expressed in Escherichia coli Thermotoga maritima

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.21.2 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 9.0, 4 mM dithiothreitol, 1.5% saturated MgSO4, 16% (w/v) ethylene glycol, 20% (w/v) polyethylene glycol monomethyl ether 2000 Thermotoga maritima

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.21.2 Mg2+ contains Mg2+ Thermotoga maritima
3.1.21.2 Mn2+ contains Mn2+, the enzyme with Mn2+ and Zn2+ is more active than with only Zn2+ Thermotoga maritima
3.1.21.2 Zn2+ contains Zn2+ Thermotoga maritima

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.2 Thermotoga maritima Q9WYJ7
-
-
3.1.21.2 Thermotoga maritima DSM 3109 Q9WYJ7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.21.2
-
 Thermotoga maritima

Synonyms

EC Number Synonyms Comment Organism
3.1.21.2 endonuclease IV
-
 Thermotoga maritima
3.1.21.2 Nfo
-
 Thermotoga maritima