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Literature summary extracted from

  • Corea, O.R.; Ki, C.; Cardenas, C.L.; Kim, S.J.; Brewer, S.E.; Patten, A.M.; Davin, L.B.; Lewis, N.G.
    Arogenate dehydratase isoenzymes profoundly and differentially modulate carbon flux into lignins (2012), J. Biol. Chem., 287, 11446-11459.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.91 genes adt1-adt6, complementation of the adt5 KO line with ADT5 gene expression under the control of its native promoter or the cauliflower mosaic virus 35S promoter Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.91 additional information homozygous T-DNA insertion lines are generated for five of the six ADT isozymes and used to generate double, triple, and quadruple knockout mutants in different combinations. The various mutants so obtained give phenotypes with profound but distinct reductions in lignin amounts, encompassing a range spanning from near wild-type levels to reductions of up to about 68%. In the various KO mutants, there are also marked changes in guaiacyl:syringyl ratios ranging from 3:1 to 1:1, respectively, due to differential carbon flux into vascular bundles versus that into fiber cells Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.91 chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.91 L-arogenate Arabidopsis thaliana
-
 L-phenylalanine + H2O + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.91 Arabidopsis thaliana
-
 six isozymes encoded by genes adt1-adt6
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.91 stem expression patterns in of isozymes ADT4 and ADT5, histochemic analysis of wild-type and knockout mutant lines, overview Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.91 L-arogenate
-
 Arabidopsis thaliana L-phenylalanine + H2O + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.91 AdT
-
 Arabidopsis thaliana

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.91 37
-
 assay at Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.91 8
-
 assay at Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
4.2.1.91 malfunction phenotypes of adt isozyme knockout mutants, overview Arabidopsis thaliana