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Literature summary extracted from

  • Kimata, T.; Tanizawa, Y.; Can, Y.; Ikeda, S.; Kuhara, A.; Mori, I.
    Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans (2012), Genetics, 191, 509-521.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 Li+ lithium impairs neuronal phosphatidylinositol 4,5-bisphosphate synthesis through inhibition of the enzyme Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.25 myo-inositol phosphate + H2O Caenorhabditis elegans
-
 myo-inositol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 myo-inositol phosphate + H2O
-
 Caenorhabditis elegans myo-inositol + phosphate
-
 ?
3.1.3.25 phosphatidylinositol 4,5-bisphosphate + H2O
-
 Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.25 IMPase
-
 Caenorhabditis elegans
3.1.3.25 myo-inositol monophosphatase
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
3.1.3.25 malfunction mutations that degrade membrane phosphatidylinositol 4,5-bisphosphate suppress the synaptic defects of the enzyme mutants and confer resistance to lithium treatment Caenorhabditis elegans
3.1.3.25 physiological function the enzyme is essential for polarized localization of synaptic molecules Caenorhabditis elegans