Literature summary extracted from
Aby, E.; Gumps, K.; Roth, A.; Sigmon, S.; Jenkins, S.E.; Kim, J.J.; Kramer, N.J.; Parfitt, K.D.; Korey, C.A.
Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae (2014), Fly, 7, 267-279.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
3.1.2.22 |
- |
Drosophila melanogaster |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.1.2.22 |
A179T |
loss-of-function mutant, shows an increased frequency of mini excitatory junctional potentials, defects in vesicle cycling during and following repetitive stimulation, and a decreased rate of fluorescent endocytic tracer FM1-43 endocytosis |
Drosophila melanogaster |
3.1.2.22 |
S77F |
loss-of-function mutant, shows an increased frequency of mini excitatory junctional potentials, defects in vesicle cycling during and following repetitive stimulation, and a decreased rate of fluorescent endocytic tracer FM1-43 endocytosis |
Drosophila melanogaster |
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.1.2.22 |
Drosophila melanogaster |
Q9W3C7 |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
3.1.2.22 |
larva |
- |
Drosophila melanogaster |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
3.1.2.22 |
physiological function |
mutations in palmitoyl-protein thioesterase Ppt1 genetically interact with temperature sensitive mutations in the Drosophila dynamin gene shibire, accelerating the paralytic behavior of shibire mutants at 27°C. Ppt1-deficient larvae show an increase in miniature excitatory junctional potentials and a significant depression of evoked excitatory junctional potentials in response to repetitive stimulation. In Ppt1-mutant larvae, there is a significant decrease in fluorescent endocytic tracer FM1-43 uptake at the mutant neuromuscular junction. Ppt1-deficient and Ppt1 point mutant larvae display defects in locomotion that are consistent with alterations in synaptic function |
Drosophila melanogaster |