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Literature summary extracted from

  • Xie, X.; Dubrovskaya, V.; Yacoub, N.; Walska, J.; Gleason, T.; Reid, K.; Dubrovsky, E.B.
    Developmental roles of Drosophila tRNA processing endonuclease RNase ZL as revealed with a conditional rescue system (2013), Dev. Biol., 381, 324-340.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.1.26.11 Drosophila melanogaster
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.26.11 central nervous system predominant expression during the third larval instar Drosophila melanogaster
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3.1.26.11 fat body
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 Drosophila melanogaster
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3.1.26.11 gonad
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 Drosophila melanogaster
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3.1.26.11 gut
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 Drosophila melanogaster
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3.1.26.11 larva
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 Drosophila melanogaster
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3.1.26.11 prepupa
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 Drosophila melanogaster
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3.1.26.11 salivary gland
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 Drosophila melanogaster
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3.1.26.11 testis
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 Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
3.1.26.11 RNase ZL
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 Drosophila melanogaster
3.1.26.11 RNaseZ
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.1.26.11 malfunction RNZED24 knockout mutation causes early larval lethality. RNaseZ knockout completely blocks tRNA maturation without diminishing the abundance of mature tRNA molecules, affects the nuclear-cytoplasmic distribution of tRNA, decreases cell proliferation but not cell survival, and affects maginal disc growth autonomously Drosophila melanogaster
3.1.26.11 physiological function RNase Z activity is essential for all phases of fly development that involve cell division, including growth of adult tissue progenitors during larval and metamorphic stages, and gametogenesis in adults Drosophila melanogaster