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Literature summary extracted from
- Identification of the first bacterial monoterpene cyclase, a 1,8-cineole synthase, that catalyzes the direct conversion of geranyl diphosphate (2011), ChemBioChem, 12, 1988-1991.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.3.108 | expression in Escherichia coli | Streptomyces clavuligerus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.108 | 0.00017 | - |
geranyl diphosphate | pH 8.0, 30°C | Streptomyces clavuligerus |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.3.108 | 40000 | - |
x * 40000, SDS-PAGE | Streptomyces clavuligerus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.3.108 | Streptomyces clavuligerus | B5GMG2 | - |
- |
| 4.2.3.108 | Streptomyces clavuligerus DSM 738 | B5GMG2 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.108 | geranyl diphosphate + H2O | - |
Streptomyces clavuligerus | 1,8-cineole + diphosphate | 1,8-cineole is the single major product | ? | |
| 4.2.3.108 | geranyl diphosphate + H2O | - |
Streptomyces clavuligerus DSM 738 | 1,8-cineole + diphosphate | 1,8-cineole is the single major product | ? | |
| 4.2.3.108 | additional information | no substrate: farnesyl diphosphate | Streptomyces clavuligerus | ? | - |
? | |
| 4.2.3.108 | additional information | no substrate: farnesyl diphosphate | Streptomyces clavuligerus DSM 738 | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.3.108 | ? | x * 40000, SDS-PAGE | Streptomyces clavuligerus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.3.108 | SCLAV_p0982 | - |
Streptomyces clavuligerus |
| 4.2.3.108 | SSCG_00536 | - |
Streptomyces clavuligerus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.108 | 0.079 | - |
geranyl diphosphate | pH 8.0, 30°C | Streptomyces clavuligerus | |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.3.108 | 460 | - |
geranyl diphosphate | pH 8.0, 30°C | Streptomyces clavuligerus | |
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