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Literature summary extracted from

  • Pereira, A.R.; Reed, P.; Veiga, H.; Pinho, M.G.
    The Holliday junction resolvase RecU is required for chromosome segregation and DNA damage repair in Staphylococcus aureus (2013), BMC Microbiol., 13, 18.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.10 Staphylococcus aureus
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3.1.21.10 Staphylococcus aureus NCTC8325-4
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Synonyms

EC Number Synonyms Comment Organism
3.1.21.10 crossover junction endodeoxyribonuclease
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Staphylococcus aureus
3.1.21.10 HJ resolvase
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Staphylococcus aureus
3.1.21.10 Holliday junction resolvase
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Staphylococcus aureus
3.1.21.10 RecU
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Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.1.21.10 malfunction enzyme depletion results in the appearance of cells with compact nucleoids, septa formed over the DNA and anucleate cells. Enzyme-depleted cells also show increased septal recruitment of the DNA translocase SpoIIIE, presumably to resolve chromosome segregation defects. Additionally cells are more sensitive to DNA damaging agents such as mitomycin C or UV radiation Staphylococcus aureus
3.1.21.10 physiological function the enzyme is required for chromosome segregation and DNA damage repair Staphylococcus aureus