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Literature summary extracted from

  • Miller, D.; Wang, Y.; Xu, H.; Harich, K.; White, R.H.
    Biosynthesis of the 5-(aminomethyl)-3-furanmethanol moiety of methanofuran (2014), Biochemistry, 53, 4635-4647.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.108 expression in Escherichia coli Methanocaldococcus jannaschii
4.2.3.153 expression in Escherichia coli Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.108 L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate Methanocaldococcus jannaschii the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
-
 ?
2.6.1.108 L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate Methanocaldococcus jannaschii DSM 2661 the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
-
 ?
4.2.3.153 D-glyceraldehyde 3-phosphate + glycerone phosphate Methanocaldococcus jannaschii the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O (5-formylfuran-3-yl)methyl phosphate i.e. 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate ?
4.2.3.153 D-glyceraldehyde 3-phosphate + glycerone phosphate Methanocaldococcus jannaschii DSM 2661 the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O (5-formylfuran-3-yl)methyl phosphate i.e. 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.108 Methanocaldococcus jannaschii Q58097
-
-
2.6.1.108 Methanocaldococcus jannaschii DSM 2661 Q58097
-
-
4.2.3.153 Methanocaldococcus jannaschii Q58499
-
-
4.2.3.153 Methanocaldococcus jannaschii DSM 2661 Q58499
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.108
-
 Methanocaldococcus jannaschii
4.2.3.153
-
 Methanocaldococcus jannaschii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.108 L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate
-
 Methanocaldococcus jannaschii pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
-
 ?
2.6.1.108 L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane Methanocaldococcus jannaschii pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
-
 ?
2.6.1.108 L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate
-
 Methanocaldococcus jannaschii DSM 2661 pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
-
 ?
2.6.1.108 L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane Methanocaldococcus jannaschii DSM 2661 pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
-
 ?
4.2.3.153 D-glyceraldehyde 3-phosphate + glycerone phosphate the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane Methanocaldococcus jannaschii (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O (5-formylfuran-3-yl)methyl phosphate i.e. 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate ?
4.2.3.153 D-glyceraldehyde 3-phosphate + glycerone phosphate the enzyme is not able to use pyruvate as substrate Methanocaldococcus jannaschii (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O (5-formylfuran-3-yl)methyl phosphate i.e. 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate ?
4.2.3.153 D-glyceraldehyde 3-phosphate + glycerone phosphate the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane Methanocaldococcus jannaschii DSM 2661 (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O (5-formylfuran-3-yl)methyl phosphate i.e. 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate ?
4.2.3.153 D-glyceraldehyde 3-phosphate + glycerone phosphate the enzyme is not able to use pyruvate as substrate Methanocaldococcus jannaschii DSM 2661 (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O (5-formylfuran-3-yl)methyl phosphate i.e. 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.108 4-HFC-P:alanine aminotransferase
-
 Methanocaldococcus jannaschii
2.6.1.108 mfnC
-
 Methanocaldococcus jannaschii
2.6.1.108 MJ0684 locus name Methanocaldococcus jannaschii
4.2.3.153 2-furaldehyde phosphate synthase
-
 Methanocaldococcus jannaschii
4.2.3.153 4-HFC-P synthase
-
 Methanocaldococcus jannaschii
4.2.3.153 mfnB
-
 Methanocaldococcus jannaschii
4.2.3.153 MJ1099 locus name Methanocaldococcus jannaschii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.108 70
-
 assay at Methanocaldococcus jannaschii
4.2.3.153 70
-
 assay at Methanocaldococcus jannaschii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.108 7.5
-
 assay at Methanocaldococcus jannaschii
4.2.3.153 6.5
-
 assay at Methanocaldococcus jannaschii

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.108 pyridoxal 5'-phosphate a pyridoxal 5'-phosphate protein Methanocaldococcus jannaschii

General Information

EC Number General Information Comment Organism
2.6.1.108 physiological function the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane Methanocaldococcus jannaschii
4.2.3.153 physiological function the enzyme is involved in biosynthesis of methanofuran, a coenzyme involved in the reduction of carbon dioxide to methane Methanocaldococcus jannaschii