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Literature summary extracted from

  • Morisseau, C.; Schebb, N.H.; Dong, H.; Ulu, A.; Aronov, P.A.; Hammock, B.D.
    Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids (2012), Biochem. Biophys. Res. Commun., 419, 796-800.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.106
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.106 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate 32% inhibition Homo sapiens
3.1.3.106 1-myristoyl-2-lyso-sn-glycerol 3-phosphate 63% inhibition Homo sapiens
3.1.3.106 1-oleoyl-2-lyso-sn-glycerol 3-phosphate 24% inhibition Homo sapiens
3.1.3.106 dodecyl phosphate 99% inhibition Homo sapiens
3.1.3.106 geranyl diphosphate 30% inhibition Homo sapiens
3.1.3.106 N-acetyl-ceramide-phosphate 30% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.106 0.0042
-
 1-stearyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 0.0051
-
 1-myristoyl-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 0.0069
-
 1-oleoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 0.013
-
 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.106 Homo sapiens P34913
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.106 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-arachidonoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-myristoyl-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-myristoylglycerol + phosphate
-
 ?
3.1.3.106 1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-oleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-stearoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-stearoylglycerol + phosphate
-
 ?
3.1.3.106 attophos A + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.106 125
-
 1-stearyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 177
-
 1-oleoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 250
-
 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 354
-
 1-myristoyl-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.106 physiological function bifunctional enzyme displaying C-terminal epoxide hydrolase and N-terminal phosphatase activity. The phosphatase activity represents a 20-60% of lysophosphatidic acid cellular hydrolysis, especially in the cytosol Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.1.3.106 20000
-
 1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 25000
-
 1-oleoyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 33000
-
 1-stearyl-2-lyso-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens
3.1.3.106 76000
-
 1-myristoyl-sn-glycerol 3-phosphate pH 7.0, 30°C Homo sapiens