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Literature summary extracted from

  • Kumagai, T.; Ishino, T.; Nakagawa, Y.
    Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells (2012), Arch. Biochem. Biophys., 519, 8-16.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information knockdown of the nezyme by siRNA, The TNF receptor 1 is migrated into the lipid raft in diethyl malate-treated cells or ASMase-overexpressing cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O Homo sapiens
-
 a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 bladder carcinoma cell
-
 Homo sapiens
-
3.1.4.12 ECV-304 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O
-
 Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?
3.1.4.12 a sphingomyelin + H2O 6-N-(7-nitro-benz-2-oxa-1,3-diazol-4-yl)aminosphingomyelin is used as substrate Homo sapiens a ceramide + phosphocholine a ceramide is an N-acylsphingosine ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acidic sphingomyelinase
-
 Homo sapiens
3.1.4.12 aSMase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5.5
-
 assay at Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.4.12 Homo sapiens electrophilic compounds such as diethyl malate, methyl mercury, and cigarette smoke extracts significantly enhanced the expression of acidic sphingomyelinase 6fold in bladder carcinoma ECV-304 cells up

General Information

EC Number General Information Comment Organism
3.1.4.12 physiological function role for the enzyme in the acceleration of the production of TNF-induced interleukin-6 as a pro-inflammatory cytokine, electrophiles can potentiate inflammation response by up-regulating of ASMase expression following formation of lipid rafts. Expression of ASMase facilitates the clustering of TNFR1 in the lipid raft that in turn enhanced the sensibility of TNF-alpha for the production of interleukin-6 Homo sapiens