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Literature summary extracted from

  • Liu, Y.; Nakamura, A.; Nakazawa, Y.; Asano, N.; Ford, K.A.; Hohn, M.J.; Tanaka, I.; Yao, M.; Söll, D.
    Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea (2014), Proc. Natl. Acad. Sci. USA, 111, 10520-10505.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.73 translation factor SepCysE essential for methanococcal Cys biosynthesis. Its deletion in Methanococcus maripaludiscauses Cys auxotrophy. SepCysE acts as a scaffold for O-phospho-L-serine—tRNA ligase (EC 6.1.1.27) and O-phospho-L-seryl-tRNA:Cys-tRNA synthase to form a stable high-affinity complex for tRNACys causing a 14fold increase in the initial rate of Cys-tRNACys formation Methanocaldococcus jannaschii

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.73 crystal structure of the complex of the enzyme with translation factor SepCysE, 2.8 A resolution Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.73 Methanocaldococcus jannaschii Q59072
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2.5.1.73 Methanocaldococcus jannaschii DSM 2661 Q59072
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Synonyms

EC Number Synonyms Comment Organism
2.5.1.73 SepCysS
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 Methanocaldococcus jannaschii