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Literature summary extracted from

  • Battenberg, O.A.; Yang, Y.; Verhelst, S.H.; Sieber, S.A.
    Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification (2013), Mol. Biosyst., 9, 343-351.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.11 expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.11 (E)-3-(3-ethynyl-4-hydroxyphenyl)-1-(2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one
-
 Staphylococcus aureus
6.1.1.11 4-hydroxyderricin
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.11 ATP + L-serine + tRNASer Staphylococcus aureus
-
 AMP + diphosphate + L-seryl-tRNASer
-
 ?
6.1.1.11 ATP + L-serine + tRNASer Staphylococcus aureus NCTC 8325
-
 AMP + diphosphate + L-seryl-tRNASer
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.11 Staphylococcus aureus
-
-
-
6.1.1.11 Staphylococcus aureus NCTC 8325
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.11 ATP + L-serine + tRNASer
-
 Staphylococcus aureus AMP + diphosphate + L-seryl-tRNASer
-
 ?
6.1.1.11 ATP + L-serine + tRNASer
-
 Staphylococcus aureus NCTC 8325 AMP + diphosphate + L-seryl-tRNASer
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.11 Seryl-tRNA synthetase
-
 Staphylococcus aureus
6.1.1.11 STS
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.11 ATP
-
 Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.1.1.11 0.0238
-
 in 100 mM HEPES (pH 7.2), 10 mM MgCl2, 30 mM KCl, at 37°C Staphylococcus aureus (E)-3-(3-ethynyl-4-hydroxyphenyl)-1-(2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one