Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Halouska, S.; Fenton, R.; Zinniel, D.; Marshall, D.; Barletta, R.; Powers, R.
    Metabolomics analysis identifies D-alanine-D-alanine ligase as the primary lethal target of D-cycloserine in mycobacteria (2014), J. Proteome Res., 13, 1065-1076.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.4 D-cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of alanine racemase and D-alanine-D-alanine ligase, the latter is the primary lethal target, inhibition mechanism and physiological effects, NMR metabolomic study, overview. D-Alanine is able to effectively compete with the inhibitor for uptake Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.4 Mg2+ required Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.4 ATP + 2 D-alanine Mycobacterium tuberculosis
-
ADP + phosphate + D-alanyl-D-alanine
-
?
6.3.2.4 ATP + 2 D-alanine Mycobacterium tuberculosis H37Rv
-
ADP + phosphate + D-alanyl-D-alanine
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Mycobacterium tuberculosis
-
-
-
6.3.2.4 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + 2 D-alanine
-
Mycobacterium tuberculosis ADP + phosphate + D-alanyl-D-alanine
-
?
6.3.2.4 ATP + 2 D-alanine
-
Mycobacterium tuberculosis H37Rv ADP + phosphate + D-alanyl-D-alanine
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.4 ATP
-
Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
6.3.2.4 additional information NMR ligand binding assay for D-alanine-D-alanine ligase, overview Mycobacterium tuberculosis