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Literature summary extracted from
- Substrate specificity of a novel squalene-hopene cyclase from Zymomonas mobilis (2012), J. Mol. Catal. B, 84, 72-77.
No PubMed abstract available
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.4.99.17 | synthesis | cyclization of homofarnesol to ambroxan as well as the conversion of citronellal to 2-isopropenyl-5-methyl-cyclohexanol bythe isozyme SHC1 can be economically attractive, as both products are used in the flavour and fragrance industry | Zymomonas mobilis |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.4.99.17 | gene ZMO1548, genetic organization | Zymomonas mobilis |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.17 | squalene | Zymomonas mobilis | - |
hop-22(29)-ene + hopanol | - |
? |  |
| 5.4.99.17 | squalene | Zymomonas mobilis CP4 | - |
hop-22(29)-ene + hopanol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.17 | Zymomonas mobilis | Q5NM88 | gene ZMO1548 | - |
| 5.4.99.17 | Zymomonas mobilis CP4 | Q5NM88 | gene ZMO1548 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.17 | citronellal | - |
Zymomonas mobilis | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
| 5.4.99.17 | citronellal | - |
Zymomonas mobilis CP4 | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
| 5.4.99.17 | homofarnesol | - |
Zymomonas mobilis | ambroxan | - |
? | |
| 5.4.99.17 | homofarnesol | - |
Zymomonas mobilis CP4 | ambroxan | - |
? | |
| 5.4.99.17 | additional information | ZmoSHC1 shows cyclization of the non-natural substrates homofarnesol (C16) and citronellal (C10) in addition to hopene formation from squalene, substrate specificity, overview. ZmoSHC1 exhibits a shift of activity towards substrates of shorter chain lengths, displaying over 50fold higher conversion of homofarnesol and more than 2fold higher conversion of citronellal in comparison to squalene conversion | Zymomonas mobilis | ? | - |
? | |
| 5.4.99.17 | additional information | ZmoSHC1 shows cyclization of the non-natural substrates homofarnesol (C16) and citronellal (C10) in addition to hopene formation from squalene, substrate specificity, overview. ZmoSHC1 exhibits a shift of activity towards substrates of shorter chain lengths, displaying over 50fold higher conversion of homofarnesol and more than 2fold higher conversion of citronellal in comparison to squalene conversion | Zymomonas mobilis CP4 | ? | - |
? | |
| 5.4.99.17 | squalene | - |
Zymomonas mobilis | hop-22(29)-ene + hopanol | - |
? | |
| 5.4.99.17 | squalene | - |
Zymomonas mobilis CP4 | hop-22(29)-ene + hopanol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.17 | SHC | - |
Zymomonas mobilis |
| 5.4.99.17 | ZmoSHC1 | - |
Zymomonas mobilis |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.4.99.17 | additional information | the enzyme catalyzes the cyclization of triterpenoids via cationic intermediates in one of the most complex reactions known in biochemistry | Zymomonas mobilis |
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