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Literature summary extracted from

  • Kong, D.; Chen, C.; Wu, H.; Li, Y.; Li, J.; Ling, H.Q.
    Sequence diversity and enzyme activity of ferric-chelate reductase LeFRO1 in tomato (2013), J. Genet. Genomics, 40, 565-573.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.16.1.7 gene LeFRO1, DNA and amino acid sequence determination and analysis from 16 different cultivars, genotyping detects three types of LeFRO1 (LeFRO1MM, LeFRO1Ailsa and LeFRO1Monita) with five amino acid variations at the positions 21, 24, 112, 195 and 582 Solanum lycopersicum

Protein Variants

EC Number Protein Variants Comment Organism
1.16.1.7 A112X modification of this amino acid results in a significant reduction of enzyme activity Solanum lycopersicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.16.1.7 2 Fe(II)-siderophore + NAD+ + H+ Solanum lycopersicum
-
 2 Fe(III)-siderophore + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.16.1.7 Solanum lycopersicum
-
 16 cultivars
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.16.1.7 root
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.16.1.7 2 Fe(II)-siderophore + NAD+ + H+
-
 Solanum lycopersicum 2 Fe(III)-siderophore + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.16.1.7 ferric-chelate reductase
-
 Solanum lycopersicum
1.16.1.7 FRO1
-
 Solanum lycopersicum

Cofactor

EC Number Cofactor Comment Organism Structure
1.16.1.7 NADH
-
 Solanum lycopersicum

General Information

EC Number General Information Comment Organism
1.16.1.7 additional information Ala112 of LeFRO1 is critical for maintaining the high activity of ferric-chelate reductase, modification of this amino acid results in a significant reduction of enzyme activity. The combination of the amino acid residue Ile at the site 24 with Lys at the site 582 plays a positive role in the enzyme activity of LeFRO1, genotyping, overview Solanum lycopersicum
1.16.1.7 physiological function ferric-chelate reductase which functions in the reduction of ferric to ferrous iron on root surface is a critical protein for iron homeostasis in strategy I plants. LeFRO1 is a major ferric-chelate reductase involved in iron uptake in tomato Solanum lycopersicum