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Literature summary extracted from

  • Kana, B.D.; Weinstein, E.A.; Avarbock, D.; Dawes, S.S.; Rubin, H.; Mizrahi, V.
    Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis (2001), J. Bacteriol., 183, 7076-7086.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.7 Mycolicibacterium smegmatis Q9L8R6 subunit cydB
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7.1.1.7 Mycolicibacterium smegmatis Q9L8R7 and Q9L8R6 Q9L8R7 i.e. subunit cydA, Q9L8R6 i.e. subunit cydB
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Synonyms

EC Number Synonyms Comment Organism
7.1.1.7 CydA
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Mycolicibacterium smegmatis
7.1.1.7 CydB
-
Mycolicibacterium smegmatis

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.7 heme two- to threefold increase in cydAB gene expression upon reduction of the pO2 of the growth medium from 21 to 0.5% air saturation with concomitant increase in d-heme absorbance in spectra of membranes isolated from wild-type Mycobacterium smegmatis cultured at 1% air saturation Mycolicibacterium smegmatis

Expression

EC Number Organism Comment Expression
7.1.1.7 Mycolicibacterium smegmatis two- to threefold increase in cydAB gene expression upon reduction of the pO2 of the growth medium from 21 to 0.5% air saturation up

General Information

EC Number General Information Comment Organism
7.1.1.7 physiological function inactivation of cydA or cydB by gene disruption results in loss of d-heme absorbance at 631 nm. Inactivation of cydA has no effect on the ability of Mycobacterium smegmatis to exit from stationary phase at 37 or 42°C. No discernible growth defect of the mutant is observed under moderately aerobic conditions, while the mutant displays a significant growth disadvantage when cocultured with the wild type under extreme microaerophilia. The cydA mutant displays a competitive growth disadvantage in the presence of the terminal oxidase inhibitor, cyanide, when cocultured with wild type at 21% air saturation in an oxystat Mycolicibacterium smegmatis
7.1.1.7 physiological function inactivation of cydA or cydB gene disruption results in loss of d-heme absorbance at 631 nm Mycolicibacterium smegmatis