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Literature summary extracted from

  • Glenn, W.S.; Nims, E.; OConnor, S.E.
    Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor (2011), J. Am. Chem. Soc., 133, 19346-19349.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.9 mutant enzyme Y455W is expressed in Catharanthus roseus Lentzea aerocolonigenes

Protein Variants

EC Number Protein Variants Comment Organism
1.14.19.9 Y455W the mutant preferentially uses tryptamine as substrate Lentzea aerocolonigenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.9 tryptophan + FADH2 + Cl- + O2 + H+ Lentzea aerocolonigenes
-
 7-chloro-L-tryptophan + FAD + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.9 Lentzea aerocolonigenes Q8KHZ8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.9 tryptamine + FADH2 + Cl- + O2 + H+
-
 Lentzea aerocolonigenes 7-chloro-L-tryptamine + FAD + H2O
-
 ?
1.14.19.9 tryptophan + FADH2 + Cl- + O2 + H+
-
 Lentzea aerocolonigenes 7-chloro-L-tryptophan + FAD + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.9 RebH
-
 Lentzea aerocolonigenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.9 FADH2
-
 Lentzea aerocolonigenes