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Literature summary extracted from
- Developmental changes of catecholamine-mediating enzyme - dopamine-beta-hydroxylase and its cofactors in central and peripheral tissues and serum of long-evans rats (2012), Int. J. Biomed. Sci., 8, 194-203.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.17.1 | 0.5 | 2 | tyramine | enzyme from serum of 5-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus |  |
| 1.14.17.1 | 0.79 | - |
tyramine | enzyme from serum of 2-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus | |
| 1.14.17.1 | 0.92 | - |
tyramine | enzyme from serum of 8-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus | |
| 1.14.17.1 | 1.22 | - |
tyramine | enzyme from serum of 1-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus | |
| 1.14.17.1 | 1.37 | - |
tyramine | enzyme from serum of 12-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus | |
| 1.14.17.1 | 1.6 | - |
tyramine | enzyme from serum of 15-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus | |
| 1.14.17.1 | 2.1 | - |
tyramine | enzyme from serum of 27-weeks-old rats, at 37°C, pH not specified in the publication | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.17.1 | dopamine + ascorbate + O2 | Rattus norvegicus | - |
norepinephrine + dehydroascorbate + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.17.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.17.1 | adrenal gland | - |
Rattus norvegicus | - |
| 1.14.17.1 | brain | highest activity | Rattus norvegicus | - |
| 1.14.17.1 | brain stem | - |
Rattus norvegicus | - |
| 1.14.17.1 | caudate nucleus | - |
Rattus norvegicus | - |
| 1.14.17.1 | cerebellum | - |
Rattus norvegicus | - |
| 1.14.17.1 | cerebral cortex | - |
Rattus norvegicus | - |
| 1.14.17.1 | heart | - |
Rattus norvegicus | - |
| 1.14.17.1 | hypothalamus | - |
Rattus norvegicus | - |
| 1.14.17.1 | kidney | - |
Rattus norvegicus | - |
| 1.14.17.1 | liver | - |
Rattus norvegicus | - |
| 1.14.17.1 | lung | - |
Rattus norvegicus | - |
| 1.14.17.1 | midbrain colliculus | - |
Rattus norvegicus | - |
| 1.14.17.1 | pancreas | - |
Rattus norvegicus | - |
| 1.14.17.1 | serum | - |
Rattus norvegicus | - |
| 1.14.17.1 | small intestine | - |
Rattus norvegicus | - |
| 1.14.17.1 | spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.17.1 | dopamine + ascorbate + O2 | - |
Rattus norvegicus | norepinephrine + dehydroascorbate + H2O | - |
? | |
| 1.14.17.1 | tyramine + ascorbate + O2 | - |
Rattus norvegicus | octopamine + dehydroascorbate + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.17.1 | 3,4-dihydroxy-phenylethylamine, ascorbate: oxygen oxidoreductase (3-hydroxylating) | - |
Rattus norvegicus |
| 1.14.17.1 | DBH | - |
Rattus norvegicus |
| 1.14.17.1 | dopamine-beta-hydroxylase | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.17.1 | Rattus norvegicus | enzyme expression is highest in 5-weeks-old rats | up |
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