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Literature summary extracted from

  • Chattopadhyay, M.K.; Chen, W.; Tabor, H.
    Escherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression (2013), FEMS Microbiol. Lett., 338, 132-140.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.78 gene gss, phylogenetic and global transcriptome analyses, microarray studies comparing gss+ and DELTAgss strains of Escherichia coli show that a large number of genes are either upregulated (76 genes more than 3fold) or downregulated (35 genes more than 3fold) by the loss of the gss gene. Most significant categories of up-regulated genes include sulfur utilization, glutamine and succinate metabolism, polyamine and arginine metabolism, and purine and pyrimidine metabolism Escherichia coli
6.3.1.8 gene gss, DNA and amiino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, transcriptome analyses Escherichia coli K-12

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.78 glutathionylspermidine + H2O Escherichia coli
-
 glutathione + spermidine GspSA catalyzes the formation of a peptide bond between GSH and spermidine, cf. EC 6.3.1.8 r

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.78 Escherichia coli P0AES0 gene gss
-
6.3.1.8 Escherichia coli K-12 P0AES0 gene gss
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.78 glutathionylspermidine + H2O
-
 Escherichia coli glutathione + spermidine GspSA catalyzes the formation of a peptide bond between GSH and spermidine, cf. EC 6.3.1.8 r

Synonyms

EC Number Synonyms Comment Organism
3.5.1.78 Glutathionylspermidine synthetase/amidase
-
 Escherichia coli
3.5.1.78 GSS
-
 Escherichia coli
6.3.1.8 bifunctional glutathionylspermidine synthetase/amidase UniProt Escherichia coli K-12
6.3.1.8 Glutathionylspermidine synthetase/amidase
-
 Escherichia coli K-12

General Information

EC Number General Information Comment Organism
3.5.1.78 evolution phylogenetic distribution of Gss: Gss sequences are largely limited to certain bacteria and kinetoplastids, and are absent in a variety of invertebrate and vertebrate species, archaea, plants and some eubacteria Escherichia coli
3.5.1.78 metabolism microarray studies comparing gss+ and DELTAgss strains of Escherichia coli show that a large number of genes are either upregulated (76 genes more than 3fold) or downregulated (35 genes more than 3fold) by the loss of the gss gene. Most significant categories of up-regulated genes include sulfur utilization, glutamine and succinate metabolism, polyamine and arginine metabolism, and purine and pyrimidine metabolism Escherichia coli
6.3.1.8 additional information transcriptome analyses, overview. A large number of genes are either upregulated (76 genes more than threefold) or downregulated (35 genes more than threefold) by the loss of the gss gene Escherichia coli K-12