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Literature summary extracted from
- Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells (2012), Exp. Biol. Med. (Maywood), 237, 1007-1017.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | CVT-11127 | specific small molecule inhibitor | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | A-549 cell | - |
Homo sapiens | - |
| 1.14.19.1 | lung cancer cell | - |
Homo sapiens | - |
| 1.14.19.1 | NCI-H1299 cell | - |
Homo sapiens | - |
| 1.14.19.1 | NCI-H460 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | DELTA9 desaturase | - |
Homo sapiens |
| 1.14.19.1 | SCD1 | - |
Homo sapiens |
| 1.14.19.1 | stearoyl-CoA desaturase-1 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | ferrocytochrome b5 | - |
Homo sapiens | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.19.1 | Homo sapiens | the enzyme level is increased in human lung tumors | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | malfunction | the ablation of enzyme activity has an immediate and profound impact on the fatty acid content of cell lipids. Enzyme inhibition alters the epidermal growth factor-dependent signaling mechanism, decreases the mobility of fluid domains in plasma membranes, and reduces EGF-induced proliferation in lung cancer cells | Homo sapiens |
| 1.14.19.1 | physiological function | the enzyme activity is the most critical determinant of the monounsaturated/saturated fatty acid balance in cancer cells | Homo sapiens |
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Release 2023.1 (January 2023)
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