EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.17 | squalene | Alicyclobacillus acidocaldarius | - |
hop-22(29)-ene | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.4.99.17 | Alicyclobacillus acidocaldarius | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
5.4.99.17 | squalene = hop-22(29)-ene | catalytic mechanism, overview | Alicyclobacillus acidocaldarius |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.17 | additional information | the enzyme shows substrate diversity for polycyclization reactions, since squalene-hopene cyclases specifically address and protonate terminal double bonds of linear terpenoids, molecules with functional groups like carboxylic acids or amides can be used as substrates, overview. It is active with squalene, a C-35 squalene analogue substrate, farnesol, and geranyl geraniol, but not with geraniol, products overview | Alicyclobacillus acidocaldarius | ? | - |
? | |
5.4.99.17 | squalene | - |
Alicyclobacillus acidocaldarius | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Alicyclobacillus acidocaldarius | hop-22(29)-ene | hopanol is also formed | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.4.99.17 | SHC | - |
Alicyclobacillus acidocaldarius |
5.4.99.17 | squalene hopene cyclase | - |
Alicyclobacillus acidocaldarius |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.4.99.17 | evolution | squalene hopene cyclases are class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. The class II mechanism involves the Broensted acid sequence motif DxDD, catalytic mechanism compared to terpene cyclases, overview | Alicyclobacillus acidocaldarius |