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Literature summary extracted from

  • Assadieskandar, A.; Amini, M.; Salehi, M.; Sadeghian, H.; Alimardani, M.; Sakhteman, A.; Nadri, H.; Shafiee, A.
    Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors (2012), Bioorg. Med. Chem., 20, 7160-7166.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 4,5-bis(4-chlorophenyl)-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4,5-bis(4-fluorophenyl)-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4,5-bis(4-methoxyphenyl)-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4,5-diphenyl-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4-(4-chlorophenyl)-5-phenyl-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4-[4-(dimethylamino)phenyl]-5-(4-methoxyphenyl)-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 4-[4-(methylsulfanyl)phenyl]-5-phenyl-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 5-(4-chlorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 5-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-(methylsulfanyl)-1H-imidazole
-
 Glycine max
1.13.11.33 5-(4-chlorophenyl)-4-[4-(dimethylamino)phenyl]-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 5-(4-chlorophenyl)-4-[4-(methylsulfanyl)phenyl]-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 5-(4-fluorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-2-thiol
-
 Glycine max
1.13.11.33 5-(4-fluorophenyl)-4-[4-(methylsulfanyl)phenyl]-1H-imidazole-2-thiol
-
 Glycine max

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 linoleic acid + O2
-
 Glycine max ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-LOX
-
 Glycine max

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.0047
-
 pH 7.0, temperature not specified in the publication Glycine max 5-(4-chlorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-2-thiol
1.13.11.33 0.0057
-
 pH 7.0, temperature not specified in the publication Glycine max 4-[4-(methylsulfanyl)phenyl]-5-phenyl-1H-imidazole-2-thiol
1.13.11.33 0.0094
-
 pH 7.0, temperature not specified in the publication Glycine max 4-[4-(dimethylamino)phenyl]-5-(4-methoxyphenyl)-1H-imidazole-2-thiol
1.13.11.33 0.011
-
 pH 7.0, temperature not specified in the publication Glycine max 5-(4-fluorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-2-thiol
1.13.11.33 0.0137
-
 pH 7.0, temperature not specified in the publication Glycine max 4-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol
1.13.11.33 0.0147
-
 pH 7.0, temperature not specified in the publication Glycine max 4,5-bis(4-methoxyphenyl)-1H-imidazole-2-thiol
1.13.11.33 0.0152
-
 pH 7.0, temperature not specified in the publication Glycine max 4,5-diphenyl-1H-imidazole-2-thiol
1.13.11.33 0.0197
-
 pH 7.0, temperature not specified in the publication Glycine max 5-(4-chlorophenyl)-4-[4-(methylsulfanyl)phenyl]-1H-imidazole-2-thiol
1.13.11.33 0.0223
-
 pH 7.0, temperature not specified in the publication Glycine max 5-(4-chlorophenyl)-4-[4-(dimethylamino)phenyl]-1H-imidazole-2-thiol
1.13.11.33 0.0234
-
 pH 7.0, temperature not specified in the publication Glycine max 4,5-bis(4-fluorophenyl)-1H-imidazole-2-thiol
1.13.11.33 0.0249
-
 pH 7.0, temperature not specified in the publication Glycine max 4-(4-chlorophenyl)-5-phenyl-1H-imidazole-2-thiol
1.13.11.33 0.062
-
 pH 7.0, temperature not specified in the publication Glycine max 4,5-bis(4-chlorophenyl)-1H-imidazole-2-thiol
1.13.11.33 0.136
-
 pH 7.0, temperature not specified in the publication Glycine max 5-(4-fluorophenyl)-4-[4-(methylsulfanyl)phenyl]-1H-imidazole-2-thiol
1.13.11.33 0.25
-
 value above, pH 7.0, temperature not specified in the publication Glycine max 5-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-(methylsulfanyl)-1H-imidazole