Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Solomons, J.T.; Johnsen, U.; Schönheit, P.; Davies, C.
    3-Phosphoglycerate is an allosteric activator of pyruvate kinase from the hyperthermophilic archaeon Pyrobaculum aerophilum (2013), Biochemistry, 52, 5865-5875.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.40 3-phosphoglycerate allosteric activator. Regulation of the enzyme by a carboxylate molecule rather than a sugar phosphate may reflect a step in the evolution of glycolysis that predates the dominance of sugars in metabolism Pyrobaculum aerophilum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.40
-
 Pyrobaculum aerophilum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.40 hanging-drop vapor diffusion method at 18°C, crystal structure is determined to 2.2 A resolution Pyrobaculum aerophilum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.6 D-glyceraldehyde-3-phosphate + H2O + oxidized ferredoxin Pyrobaculum aerophilum
-
 3-phospho-D-glycerate + H+ + reduced ferredoxin
-
 ir
2.7.1.40 ATP + pyruvate Pyrobaculum aerophilum the enzyme catalyzes the final step of glycolysis ADP + phosphoenolpyruvate
-
 ?
2.7.1.40 ATP + pyruvate Pyrobaculum aerophilum DSM 7523 the enzyme catalyzes the final step of glycolysis ADP + phosphoenolpyruvate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.6 Pyrobaculum aerophilum
-
-
-
2.7.1.40 Pyrobaculum aerophilum Q8ZYE0
-
-
2.7.1.40 Pyrobaculum aerophilum DSM 7523 Q8ZYE0
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.40
-
 Pyrobaculum aerophilum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.6 D-glyceraldehyde-3-phosphate + H2O + oxidized ferredoxin
-
 Pyrobaculum aerophilum 3-phospho-D-glycerate + H+ + reduced ferredoxin
-
 ir
2.7.1.40 ATP + pyruvate
-
 Pyrobaculum aerophilum ADP + phosphoenolpyruvate
-
 ?
2.7.1.40 ATP + pyruvate the enzyme catalyzes the final step of glycolysis Pyrobaculum aerophilum ADP + phosphoenolpyruvate
-
 ?
2.7.1.40 ATP + pyruvate
-
 Pyrobaculum aerophilum DSM 7523 ADP + phosphoenolpyruvate
-
 ?
2.7.1.40 ATP + pyruvate the enzyme catalyzes the final step of glycolysis Pyrobaculum aerophilum DSM 7523 ADP + phosphoenolpyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.7.6 GAPOR
-
 Pyrobaculum aerophilum
1.2.7.6 glyceraldehyde 3-phosphate ferredoxin oxidoreductase
-
 Pyrobaculum aerophilum
2.7.1.40 PAE0819 locus name Pyrobaculum aerophilum

General Information

EC Number General Information Comment Organism
2.7.1.40 physiological function the enzyme catalyzes the final step of glycolysis Pyrobaculum aerophilum