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Literature summary extracted from
- Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis (2013), Biochem. Biophys. Res. Commun., 431, 597-603.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.98 | protopine + [reduced NADPH-hemoprotein reductase] + O2 | Papaver somniferum | hydroxylation of protopine by protopine 6-hydroxylase produces the unstable intermediate 6-hydroxyprotopine that spontaneously rearranges to form dihydrosanguinarine | 6-hydroxyprotopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
ir |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.98 | Papaver somniferum | - |
opium poppy | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.98 | protopine + [reduced NADPH-hemoprotein reductase] + O2 | hydroxylation of protopine by protopine 6-hydroxylase produces the unstable intermediate 6-hydroxyprotopine that spontaneously rearranges to form dihydrosanguinarine | Papaver somniferum | 6-hydroxyprotopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.98 | CYP82N3 | - |
Papaver somniferum |
| 1.14.14.98 | P6H | - |
Papaver somniferum |
| 1.14.14.98 | protopine 6-hydroxylase | - |
Papaver somniferum |
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Release 2023.1 (January 2023)
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