Any feedback?
Literature summary extracted from
- Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin (1981), Antimicrob. Agents Chemother., 20, 214-225.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.34 | Streptomyces fradiae | - |
- |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.15.34 | TylH | - |
Streptomyces fradiae |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.15.34 | physiological function | the tylH mutant, which is blocked in the oxidation of C-23 methyl to hydroxymethyl, is capable of carrying out all other biosynthetic steps except addition of 6-deoxy-D-allose and subsequent O-methylations and produces the biologically active compound 23-deoxydemycinosyl tylosine. A tyID tylH lacking double mutant, blocked specifically in the biosynthesis of 6-deoxy-D-allose and in specific oxidation of tylactone, accumulates 23-deoxydemycinosyl tylosin and therefore cannot oxidize the C-23 methyl position of lactone | Streptomyces fradiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
