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Literature summary extracted from

  • Zhou, R.; Jackson, L.; Shadle, G.; Nakashima, J.; Temple, S.; Chen, F.; Dixon, R.A.
    Distinct cinnamoyl CoA reductases involved in parallel routes to lignin in Medicago truncatula (2010), Proc. Natl. Acad. Sci. USA, 107, 17803-17808.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.44 expressed in Escherichia coli BL21 (DE34) cells Medicago truncatula

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.44 5-hydroxyferuloyl-CoA + NADPH + H+ Medicago truncatula
-
 5-hydroxyconiferaldehyde + CoA + NADP+
-
 ?
1.2.1.44 caffeoyl-CoA + NADPH + H+ Medicago truncatula preferred substrate for isoform CCR2 caffealdehyde + CoA + NADP+
-
 r
1.2.1.44 coumaroyl-CoA + NADPH + H+ Medicago truncatula preferred substrate for isoform CCR2 coumaric aldehyde + CoA + NADP+
-
 ?
1.2.1.44 feruloyl-CoA + NADPH + H+ Medicago truncatula preferred substrate for isoform CCR1 coniferaldehyde + CoA + NADP+
-
 ?
1.2.1.44 sinapoyl-CoA + NADPH + H+ Medicago truncatula
-
 sinapaldehyde + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.44 Medicago truncatula
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.44
-
 Medicago truncatula

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.44 5-hydroxyferuloyl-CoA + NADPH + H+
-
 Medicago truncatula 5-hydroxyconiferaldehyde + CoA + NADP+
-
 ?
1.2.1.44 caffeoyl-CoA + NADPH + H+ preferred substrate for isoform CCR2 Medicago truncatula caffealdehyde + CoA + NADP+
-
 r
1.2.1.44 coumaroyl-CoA + NADPH + H+ preferred substrate for isoform CCR2 Medicago truncatula coumaric aldehyde + CoA + NADP+
-
 ?
1.2.1.44 feruloyl-CoA + NADPH + H+ preferred substrate for isoform CCR1 Medicago truncatula coniferaldehyde + CoA + NADP+
-
 ?
1.2.1.44 sinapoyl-CoA + NADPH + H+
-
 Medicago truncatula sinapaldehyde + CoA + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.44 CCR1 isoform Medicago truncatula
1.2.1.44 CCR2 isoform Medicago truncatula
1.2.1.44 cinnamoyl CoA reductase
-
 Medicago truncatula

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.44 NADPH
-
 Medicago truncatula

Expression

EC Number Organism Comment Expression
1.2.1.44 Medicago truncatula knockout of caffeoyl CoA 3-O-methyltransferase up-regulates isoform CCR2 up

General Information

EC Number General Information Comment Organism
1.2.1.44 malfunction Ccr1 knockout mutants exhibit a dramatic decrease in S lignin in vascular tissue Medicago truncatula