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Literature summary extracted from

  • Shima, S.; Krueger, M.; Weinert, T.; Demmer, U.; Kahnt, J.; Thauer, R.K.; Ermler, U.
    Structure of a methyl-coenzyme M reductase from Black Sea mats that oxidize methane anaerobically (2012), Nature, 481, 98-101.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.8.4.1 sitting drop vapor diffusion method, using 25% (w/v) PEG 400, 0.1M Tris pH 8.5 and 0.2 M Li2SO4 uncultured archaeon

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.4.1 bromoethane sulfonate
-
 uncultured archaeon

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.4.1 280000
-
 gel filtration uncultured archaeon

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.4.1 CH3-S-CoM + HS-CoB uncultured archaeon
-
 CoM-S-S-CoB + methane
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.4.1 uncultured archaeon D1JBK2 and D1JBK3 and D1JBK4 subunits alpha, beta and gamma; consortia of microorganisms collected from a Black Sea mat (ANME-1)
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.4.1
-
 uncultured archaeon

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.4.1 CH3-S-CoM + HS-CoB
-
 uncultured archaeon CoM-S-S-CoB + methane
-
 r

Subunits

EC Number Subunits Comment Organism
2.8.4.1 heterohexamer
-
 uncultured archaeon

Synonyms

EC Number Synonyms Comment Organism
2.8.4.1 MCR
-
 uncultured archaeon
2.8.4.1 methyl-coenzyme M reductase
-
 uncultured archaeon

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.4.1 F-430 the enzyme contains the Ni porphinoid F430 as prosthetic group uncultured archaeon