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Literature summary extracted from

  • Reniere, M.L.; Ukpabi, G.N.; Harry, S.R.; Stec, D.F.; Krull, R.; Wright, D.W.; Bachmann, B.O.; Murphy, M.E.; Skaar, E.P.
    The IsdG-family of haem oxygenases degrades haem to a novel chromophore (2010), Mol. Microbiol., 75, 1529-1538.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.48
-
 Staphylococcus aureus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.14.99.48 isoform IsdI in complex with heme, heme ruffling and constrained binding of oxygen is consistent with cleavage of the porphyrin ring at the beta- or delta-meso carbon atoms Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.48 protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
1.14.99.48 protoheme + 4 AH2 + 4 O2 Staphylococcus aureus
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
1.14.99.48 protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
1.14.99.48 protoheme + 4 AH2 + 4 O2 Staphylococcus aureus N315
-
 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.48 Staphylococcus aureus Q7A649
-
-
1.14.99.48 Staphylococcus aureus Q7A827 isoform IsdI
-
1.14.99.48 Staphylococcus aureus N315 Q7A649
-
-
1.14.99.48 Staphylococcus aureus N315 Q7A827 isoform IsdI
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.48 protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
1.14.99.48 protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
1.14.99.48 protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?
1.14.99.48 protoheme + 4 AH2 + 4 O2
-
 Staphylococcus aureus N315 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O product is a red-orange solid that becomes yellow when dissolved in dimethyl sulfoxide or water/acetonitrile. It is more polar than biliverdin and bilirubin ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.48 heme oxygenase (staphylobilin-producing) 1
-
 Staphylococcus aureus
1.14.99.48 heme oxygenase (staphylobilin-producing) 2
-
 Staphylococcus aureus
1.14.99.48 isdG
-
 Staphylococcus aureus
1.14.99.48 isdI
-
 Staphylococcus aureus