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Literature summary extracted from

  • Bolusani, S.; Young, B.A.; Cole, N.A.; Tibbetts, A.S.; Momb, J.; Bryant, J.D.; Solmonson, A.; Appling, D.R.
    Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues (2011), J. Biol. Chem., 286, 5166-5174.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.5 expressed in Saccharomyces cerevisiae strain MWY4.4 and in CHO cells Homo sapiens
1.5.1.5 expressed in Saccharomyces cerevisiae strain MWY4.4 and in CHO cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.5 mitochondrion the enzyme behaves as a tightly associated peripheral membrane protein of the mitochondrial inner membrane Homo sapiens 5739
-
1.5.1.5 mitochondrion the enzyme behaves as a tightly associated peripheral membrane protein of the mitochondrial inner membrane Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.5 5,10-methylenetetrahydrofolate + NADP+ Homo sapiens
-
 5,10-methenyltetrahydrofolate + NADPH + H+
-
 ?
1.5.1.5 5,10-methylenetetrahydrofolate + NADP+ Rattus norvegicus
-
 5,10-methenyltetrahydrofolate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.5 Homo sapiens
-
-
-
1.5.1.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.5 brain
-
 Homo sapiens
-
1.5.1.5 brain
-
 Rattus norvegicus
-
1.5.1.5 heart
-
 Rattus norvegicus
-
1.5.1.5 kidney
-
 Rattus norvegicus
-
1.5.1.5 liver
-
 Rattus norvegicus
-
1.5.1.5 lung
-
 Rattus norvegicus
-
1.5.1.5 additional information the enzyme is expressed in adult tissues Homo sapiens
-
1.5.1.5 additional information the enzyme is expressed in adult tissues Rattus norvegicus
-
1.5.1.5 placenta
-
 Homo sapiens
-
1.5.1.5 placenta
-
 Rattus norvegicus
-
1.5.1.5 spleen
-
 Rattus norvegicus
-
1.5.1.5 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.5 5,10-methylenetetrahydrofolate + NADP+
-
 Homo sapiens 5,10-methenyltetrahydrofolate + NADPH + H+
-
 ?
1.5.1.5 5,10-methylenetetrahydrofolate + NADP+
-
 Rattus norvegicus 5,10-methenyltetrahydrofolate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.5 methylenetetrahydrofolate dehydrogenase
-
 Homo sapiens
1.5.1.5 methylenetetrahydrofolate dehydrogenase
-
 Rattus norvegicus
1.5.1.5 MTHFD2L
-
 Homo sapiens
1.5.1.5 MTHFD2L
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.5 NADP+ dependent on Homo sapiens
1.5.1.5 NADP+ dependent on Rattus norvegicus