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Literature summary extracted from

  • Yoshiyama-Yanagawa, T.; Enya, S.; Shimada-Niwa, Y.; Yaguchi, S.; Haramoto, Y.; Matsuya, T.; Shiomi, K.; Sasakura, Y.; Takahashi, S.; Asashima, M.; Kataoka, H.; Niwa, R.
    The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme (2011), J. Biol. Chem., 286, 25756-25762.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.21 expression in S2 cell Caenorhabditis elegans
1.3.1.21 expression in S2 cell Bombyx mori
1.14.19.21 expressed in Drosophila melanogaster S2 cells Caenorhabditis elegans
1.14.19.21 expressed in Drosophila melanogaster S2 cells Bombyx mori
1.14.19.21 expressed in Drosophila melanogaster S2 cells Xenopus laevis
1.14.19.21 expressed in Drosophila melanogaster S2 cells Danio rerio
1.14.19.21 expressed in Drosophila melanogaster S2 cells Hemicentrotus pulcherrimus

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.21 C122A mutation within Rieske [2Fe-2S]-motif, complete loss of activity Caenorhabditis elegans
1.3.1.21 D234A mutation within non-heme Fe(II) binding motif, complete loss of activity Caenorhabditis elegans
1.3.1.21 H190A mutation within Rieske [2Fe-2S]-motif, complete loss of activity Bombyx mori
1.3.1.21 H282A mutation within non-heme Fe(II) binding motif, complete loss of activity Bombyx mori
1.14.19.21 C122A inactive Caenorhabditis elegans
1.14.19.21 C178A inactive Xenopus laevis
1.14.19.21 D234A inactive Caenorhabditis elegans
1.14.19.21 H190A inactive Bombyx mori
1.14.19.21 H282A inactive Bombyx mori

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.21 microsome
-
 Caenorhabditis elegans
-
-
1.3.1.21 microsome
-
 Bombyx mori
-
-
1.14.19.21 microsome
-
 Caenorhabditis elegans
-
-
1.14.19.21 microsome
-
 Bombyx mori
-
-
1.14.19.21 microsome
-
 Xenopus laevis
-
-
1.14.19.21 microsome
-
 Danio rerio
-
-
1.14.19.21 microsome
-
 Ciona intestinalis
-
-
1.14.19.21 microsome
-
 Hemicentrotus pulcherrimus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.21 cholesterol + O2 + NADH + H+ Bombyx mori
-
 cholesta-5,7-dien-3beta-ol + NAD+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+ Caenorhabditis elegans
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+ Xenopus laevis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+ Danio rerio
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+ Ciona intestinalis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+ Hemicentrotus pulcherrimus
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+ Caenorhabditis elegans
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+ Bombyx mori
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+ Xenopus laevis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+ Danio rerio
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+ Ciona intestinalis
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+ Hemicentrotus pulcherrimus
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Bombyx mori Q1JUZ2
-
-
1.3.1.21 Caenorhabditis elegans Q17938
-
-
1.14.19.21 Bombyx mori Q1JUZ2
-
-
1.14.19.21 Caenorhabditis elegans Q17938
-
-
1.14.19.21 Ciona intestinalis F7J186
-
-
1.14.19.21 Danio rerio Q6DHJ3
-
-
1.14.19.21 Hemicentrotus pulcherrimus F7J188
-
-
1.14.19.21 Xenopus laevis F7J184
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesterol + O2 + NAD(P)H + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O
-
 ?
1.3.1.21 cholesterol + O2 + NAD(P)H + H+
-
 Bombyx mori cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+
-
 Bombyx mori cholesta-5,7-dien-3beta-ol + NAD+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+
-
 Xenopus laevis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+
-
 Danio rerio cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+
-
 Ciona intestinalis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADH + H+
-
 Hemicentrotus pulcherrimus cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+
-
 Bombyx mori cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+
-
 Xenopus laevis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+
-
 Danio rerio cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+
-
 Ciona intestinalis cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
1.14.19.21 cholesterol + O2 + NADPH + H+
-
 Hemicentrotus pulcherrimus cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 DAF-36
-
 Caenorhabditis elegans
1.3.1.21 Neverland
-
 Bombyx mori
1.3.1.21 Nvd
-
 Bombyx mori
1.14.19.21 cholesterol 7,8-dehydrogenase
-
 Caenorhabditis elegans
1.14.19.21 cholesterol 7,8-dehydrogenase
-
 Bombyx mori
1.14.19.21 cholesterol 7,8-dehydrogenase
-
 Xenopus laevis
1.14.19.21 cholesterol 7,8-dehydrogenase
-
 Danio rerio
1.14.19.21 cholesterol 7,8-dehydrogenase
-
 Ciona intestinalis
1.14.19.21 cholesterol 7,8-dehydrogenase
-
 Hemicentrotus pulcherrimus
1.14.19.21 DAF-36/Neverland
-
 Caenorhabditis elegans
1.14.19.21 DAF-36/Neverland
-
 Xenopus laevis
1.14.19.21 DAF-36/Neverland
-
 Danio rerio
1.14.19.21 DAF-36/Neverland
-
 Ciona intestinalis
1.14.19.21 DAF-36/Neverland
-
 Hemicentrotus pulcherrimus
1.14.19.21 Neverland
-
 Bombyx mori
1.14.19.21 Nvd
-
 Bombyx mori
1.14.19.21 Nvd
-
 Xenopus laevis
1.14.19.21 Nvd
-
 Danio rerio
1.14.19.21 Nvd
-
 Ciona intestinalis
1.14.19.21 Nvd
-
 Hemicentrotus pulcherrimus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.21 NADH
-
 Caenorhabditis elegans
1.14.19.21 NADH
-
 Bombyx mori
1.14.19.21 NADH
-
 Xenopus laevis
1.14.19.21 NADH
-
 Danio rerio
1.14.19.21 NADH
-
 Ciona intestinalis
1.14.19.21 NADH
-
 Hemicentrotus pulcherrimus
1.14.19.21 NADPH
-
 Caenorhabditis elegans
1.14.19.21 NADPH
-
 Bombyx mori
1.14.19.21 NADPH
-
 Xenopus laevis
1.14.19.21 NADPH
-
 Danio rerio
1.14.19.21 NADPH
-
 Ciona intestinalis
1.14.19.21 NADPH
-
 Hemicentrotus pulcherrimus
1.14.19.21 [2Fe-2S]-center
-
 Caenorhabditis elegans
1.14.19.21 [2Fe-2S]-center
-
 Bombyx mori
1.14.19.21 [2Fe-2S]-center
-
 Xenopus laevis
1.14.19.21 [2Fe-2S]-center
-
 Danio rerio
1.14.19.21 [2Fe-2S]-center
-
 Ciona intestinalis
1.14.19.21 [2Fe-2S]-center
-
 Hemicentrotus pulcherrimus

General Information

EC Number General Information Comment Organism
1.3.1.21 physiological function wild-type Bombyx mori enzyme rescues the lethality of Drosophila melanogaster animals treated with RNAi against the nvd gene, whereas Bombyx mori mutants H190A and H282A do not Bombyx mori