Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lodder-Gadaczek, J.; Becker, I.; Gieselmann, V.; Wang-Eckhardt, L.; Eckhardt, M.
    N-Acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate (2011), J. Biol. Chem., 286, 16693-16706.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.41 expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells Mus musculus
6.3.2.42 expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells Mus musculus
6.3.2.42 expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells. Because hexahistidine-tagged Escherichia coli-expressed enzyme using bacterial expressed protein Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.2.41 cytosol
-
 Mus musculus 5829
-
6.3.2.42 cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.41 42000
-
 x * 42000, SDS-PAGE Mus musculus
6.3.2.42 42000
-
 x * 42000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.41 ATP + N-acetyl-L-aspartate + L-glutamate Mus musculus
-
 ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
-
 ?
6.3.2.42 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate Mus musculus
-
 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?
6.3.2.42 ATP + N-acetyl-L-aspartate + L-glutamate Mus musculus
-
 ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.41 Mus musculus
-
-
-
6.3.2.42 Mus musculus
-
-
-
6.3.2.42 Mus musculus Q6PFX8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.41 brain
-
 Mus musculus
-
6.3.2.41 brain stem
-
 Mus musculus
-
6.3.2.41 cerebellum
-
 Mus musculus
-
6.3.2.41 forebrain
-
 Mus musculus
-
6.3.2.41 kidney
-
 Mus musculus
-
6.3.2.41 sciatic nerve
-
 Mus musculus
-
6.3.2.41 spinal cord
-
 Mus musculus
-
6.3.2.41 testis
-
 Mus musculus
-
6.3.2.41 thymus
-
 Mus musculus
-
6.3.2.42 brain
-
 Mus musculus
-
6.3.2.42 brain stem
-
 Mus musculus
-
6.3.2.42 central nervous system highest expression levels in the brain stem and spinal cord, almost undetectable in the neocortex Mus musculus
-
6.3.2.42 cerebellum
-
 Mus musculus
-
6.3.2.42 cerebellum strong expression is restricted to deep cerebellar nuclei Mus musculus
-
6.3.2.42 forebrain
-
 Mus musculus
-
6.3.2.42 kidney
-
 Mus musculus
-
6.3.2.42 sciatic nerve
-
 Mus musculus
-
6.3.2.42 spinal cord
-
 Mus musculus
-
6.3.2.42 spinal cord expression is found in the ventral and dorsal horns of gray matter in laminae III to X, but is low or absent in laminae I and II Mus musculus
-
6.3.2.42 testis
-
 Mus musculus
-
6.3.2.42 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.41 ATP + N-acetyl-L-aspartate + L-glutamate
-
 Mus musculus ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
-
 ?
6.3.2.42 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
-
 Mus musculus 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?
6.3.2.42 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate the enzyme also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase Mus musculus 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?
6.3.2.42 ATP + N-acetyl-L-aspartate + L-glutamate
-
 Mus musculus ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.41 ? x * 42000, SDS-PAGE Mus musculus
6.3.2.42 ? x * 42000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.3.2.41 N-acetylaspartylglutamate synthetase II
-
 Mus musculus
6.3.2.41 NAAGS-II
-
 Mus musculus
6.3.2.42 N-acetylaspartylglutamate synthetase II
-
 Mus musculus
6.3.2.42 N-acetylaspartylglutamylglutamate synthetase
-
 Mus musculus
6.3.2.42 NAAG synthetase II
-
 Mus musculus
6.3.2.42 NAAG(2) synthase
-
 Mus musculus
6.3.2.42 NAAGS-II
-
 Mus musculus
6.3.2.42 RIMKLA gene name, ambiguous Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.41 ATP
-
 Mus musculus
6.3.2.42 ATP
-
 Mus musculus