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Literature summary extracted from

  • Viola, R.E.; Faehnle, C.R.; Blanco, J.; Moore, R.A.; Liu, X.; Arachea, B.T.; Pavlovsky, A.G.
    The catalytic machinery of a key enzyme in amino acid biosynthesis (2011), J. Amino Acids, 2011, 352538.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.11 C136S the mutation virtually eliminates catalysis Haemophilus influenzae
1.2.1.11 E243D the mutant shows 1.2% activity compared to the wild type enzyme Haemophilus influenzae
1.2.1.11 H277N the mutant shows 1% activity compared to the wild type enzyme Haemophilus influenzae
1.2.1.11 K246R the mutant shows 3.3% activity compared to the wild type enzyme Haemophilus influenzae
1.2.1.11 R103K the mutant shows 0.4% activity compared to the wild type enzyme Haemophilus influenzae
1.2.1.11 R103L the mutant shows 0.07% activity compared to the wild type enzyme Haemophilus influenzae
1.2.1.11 R267L the mutant shows 9.5% activity compared to the wild type enzyme Haemophilus influenzae
1.2.1.11 R270K the mutant shows 0.1% activity compared to the wild type enzyme Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Escherichia coli
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Streptococcus pneumoniae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Candida albicans
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Methanocaldococcus jannaschii
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Haemophilus influenzae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+ Vibrio cholerae
-
 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Candida albicans
-
-
-
1.2.1.11 Escherichia coli
-
-
-
1.2.1.11 Haemophilus influenzae P44801
-
-
1.2.1.11 Methanocaldococcus jannaschii
-
-
-
1.2.1.11 Streptococcus pneumoniae
-
-
-
1.2.1.11 Vibrio cholerae Q9KQG2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Escherichia coli L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Streptococcus pneumoniae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Candida albicans L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Methanocaldococcus jannaschii L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Haemophilus influenzae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-4-aspartyl phosphate + NADPH + H+
-
 Vibrio cholerae L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Escherichia coli L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Streptococcus pneumoniae L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Candida albicans L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Methanocaldococcus jannaschii L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Haemophilus influenzae L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Vibrio cholerae L-4-aspartyl phosphate + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.2.1.11 homodimer
-
 Escherichia coli
1.2.1.11 homodimer
-
 Streptococcus pneumoniae
1.2.1.11 homodimer
-
 Candida albicans
1.2.1.11 homodimer
-
 Methanocaldococcus jannaschii
1.2.1.11 homodimer
-
 Haemophilus influenzae
1.2.1.11 homodimer
-
 Vibrio cholerae

Synonyms

EC Number Synonyms Comment Organism
1.2.1.11 ASADH
-
 Escherichia coli
1.2.1.11 ASADH
-
 Streptococcus pneumoniae
1.2.1.11 ASADH
-
 Candida albicans
1.2.1.11 ASADH
-
 Methanocaldococcus jannaschii
1.2.1.11 ASADH
-
 Haemophilus influenzae
1.2.1.11 ASADH
-
 Vibrio cholerae
1.2.1.11 aspartate-beta-semialdehyde dehydrogenase
-
 Escherichia coli
1.2.1.11 aspartate-beta-semialdehyde dehydrogenase
-
 Streptococcus pneumoniae
1.2.1.11 aspartate-beta-semialdehyde dehydrogenase
-
 Candida albicans
1.2.1.11 aspartate-beta-semialdehyde dehydrogenase
-
 Methanocaldococcus jannaschii
1.2.1.11 aspartate-beta-semialdehyde dehydrogenase
-
 Haemophilus influenzae
1.2.1.11 aspartate-beta-semialdehyde dehydrogenase
-
 Vibrio cholerae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADP+
-
 Escherichia coli
1.2.1.11 NADP+
-
 Streptococcus pneumoniae
1.2.1.11 NADP+
-
 Candida albicans
1.2.1.11 NADP+
-
 Methanocaldococcus jannaschii
1.2.1.11 NADP+
-
 Haemophilus influenzae
1.2.1.11 NADP+
-
 Vibrio cholerae
1.2.1.11 NADPH
-
 Escherichia coli
1.2.1.11 NADPH
-
 Streptococcus pneumoniae
1.2.1.11 NADPH
-
 Candida albicans
1.2.1.11 NADPH
-
 Methanocaldococcus jannaschii
1.2.1.11 NADPH
-
 Haemophilus influenzae
1.2.1.11 NADPH
-
 Vibrio cholerae

General Information

EC Number General Information Comment Organism
1.2.1.11 metabolism aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway Escherichia coli
1.2.1.11 metabolism aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway Streptococcus pneumoniae
1.2.1.11 metabolism aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway Candida albicans
1.2.1.11 metabolism aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway Methanocaldococcus jannaschii
1.2.1.11 metabolism aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway Haemophilus influenzae
1.2.1.11 metabolism aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway Vibrio cholerae