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Literature summary extracted from

  • Melancon, C.E. 3rd; Takahashi, H.; Liu, H.W.
    Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis (2004), J. Am. Chem. Soc., 126, 16726-16727.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.316 tylM3 protein activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene Streptomyces fradiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.316 expression in double mutant (KdesI/KdesVII) of Streptomyces venezuelae Streptomyces fradiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.316 tylactone + dTDP-alpha-D-mycaminose Streptomyces fradiae the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin dTDP + 5-O-beta-D-mycaminosyltylactone
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.316 Streptomyces fradiae P95747
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.316 tylactone + dTDP-alpha-D-mycaminose the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae dTDP + 5-O-beta-D-mycaminosyltylactone
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 ?
2.4.1.316 tylactone + dTDP-alpha-D-mycaminose the enzyme is flexible toward the acceptor substrate, glycosylating 16-membered tylactone and 12-membered ring macrolide Streptomyces fradiae dTDP + 5-O-beta-D-mycaminosyltylactone
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.316 TylM2
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 Streptomyces fradiae

General Information

EC Number General Information Comment Organism
2.4.1.316 physiological function the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae