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Literature summary extracted from

  • Monteiro, R.; Becker, H.; Azevedo, I.; Calhau, C.
    Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity (2006), J. Agric. Food Chem., 54, 2938-2943.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.14 8-prenylnaringenin flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression Homo sapiens
1.14.14.14 isoxanthohumol flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression Homo sapiens
1.14.14.14 additional information lager beer, alcohol-free beer, stout beer, and xanthohumol-rich stout beer significantly decrease aromatase activity Homo sapiens
1.14.14.14 xanthohumol flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.14 Homo sapiens
-
-
-
1.14.14.14 Homo sapiens ATCC HTB-144
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.14 JAR cell trophoblastic tumor cell of placenta Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.14.14 0.000065
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 8-prenylnaringenin
1.14.14.14 0.0203
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens xanthohumol
1.14.14.14 0.081
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens isoxanthohumol