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Literature summary extracted from

  • Wilson, V.T.; Cundliffe, E.
    Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae (1998), Gene, 214, 95-100.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.317 46635
-
 x * 46635, calculated from sequence Streptomyces fradiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.317 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose Streptomyces fradiae the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin dTDP + demethyllactenocin demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-beta-D-allopyranoside ?
2.4.1.317 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose Streptomyces fradiae T59235 the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin dTDP + demethyllactenocin demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-beta-D-allopyranoside ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.317 Streptomyces fradiae O70023
-
-
2.4.1.317 Streptomyces fradiae T59235 O70023
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.317 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose
-
 Streptomyces fradiae dTDP + demethyllactenocin demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-beta-D-allopyranoside ?
2.4.1.317 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae dTDP + demethyllactenocin demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-beta-D-allopyranoside ?
2.4.1.317 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose
-
 Streptomyces fradiae T59235 dTDP + demethyllactenocin demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-beta-D-allopyranoside ?
2.4.1.317 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae T59235 dTDP + demethyllactenocin demethyllactenocin i.e. [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-beta-D-allopyranoside ?

Subunits

EC Number Subunits Comment Organism
2.4.1.317 ? x * 46635, calculated from sequence Streptomyces fradiae

Synonyms

EC Number Synonyms Comment Organism
2.4.1.317 tylN
-
 Streptomyces fradiae

General Information

EC Number General Information Comment Organism
2.4.1.317 physiological function the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin Streptomyces fradiae