EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | glutathione disulfide + NADPH + H+ | Mus musculus | - |
glutathione + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.7 | Mus musculus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | glutathione disulfide + NADPH + H+ | - |
Mus musculus | glutathione + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.7 | Gsr | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | NADPH | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.8.1.7 | malfunction | enzyme-deficient mice exhibit increased morbidity and mortality but do not exhibit a greater sensitivity to lipopolysaccharide than do wild type mice. Neutrophils of enzyme-deficient mice reveal impaired phagocytosis | Mus musculus |
1.8.1.7 | physiological function | glutathione reductase is essential for host defense against bacterial (group B Streptococcus) infection. The oxidative defense mechanism mediated by the enzyme is required for an effective innate immune response against bacteria, probably by preventing phagocyte dysfunction due to oxidative damage | Mus musculus |