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Literature summary extracted from

  • Grivennikova, V.G.; Gladyshev, G.V.; Vinogradov, A.D.
    Allosteric nucleotide-binding site in the mitochondrial NADH:ubiquinone oxidoreductase (respiratory complex I) (2011), FEBS Lett., 585, 2212-2216.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.2 ADP 4.5fold activation of NADH:ubiquinone oxidoreductase at 0.1 M Bos taurus
7.1.1.2 ATP 10fold activation of NADH:ubiquinone oxidoreductase at 0.1 M, ATP in the micromolar concentration range specifically stimulates the NADH:hexaammineruthenium(III) (HAR) reductase activity catalyzed by eukaryotic complex I when assayed at low NADH and acceptor concentrations Bos taurus
7.1.1.2 ATP ATP in the micromolar concentration range specifically stimulates the NADH:hexaammineruthenium(III) (HAR) reductase activity catalyzed by eukaryotic complex I when assayed at low NADH and acceptor concentrations Yarrowia lipolytica
7.1.1.2 additional information no activation by adenylylimidodiphosphate, GTP, GDP, adenosine, AMP, cAMP, and CTP Bos taurus
7.1.1.2 additional information no stimulation of the three-subunit FP fragment of complex I or for membrane-bound NDH-1 by ATP Paracoccus denitrificans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion submitochondrial fragments Bos taurus 5739
-
7.1.1.2 mitochondrion submitochondrial fragments Yarrowia lipolytica 5739
-
7.1.1.2 plasma membrane
-
 Paracoccus denitrificans 5886
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-
7.1.1.2 Paracoccus denitrificans
-
-
-
7.1.1.2 Yarrowia lipolytica
-
 var. alkalitolerance
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 additional information the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity Bos taurus ?
-
 ?
7.1.1.2 additional information the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity Yarrowia lipolytica ?
-
 ?
7.1.1.2 additional information the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity. The enzyme NDH-1 catalyzes a number of the NADH:artificial electron acceptor oxidoreductase activities showing particularly high turnover numbers with ferricyanide and hexaammineruthenium(III), kinetic patterns of the steady-state NADH oxidation with these two electron acceptors, overview Paracoccus denitrificans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 mitochondrial NADH:ubiquinone oxidoreductase
-
 Bos taurus
7.1.1.2 mitochondrial NADH:ubiquinone oxidoreductase
-
 Yarrowia lipolytica
7.1.1.2 NADH:HAR reductase
-
 Paracoccus denitrificans
7.1.1.2 NADH:HAR reductase
-
 Bos taurus
7.1.1.2 NADH:HAR reductase
-
 Yarrowia lipolytica
7.1.1.2 NDH-1 prokaryotic complex I homolog Paracoccus denitrificans
7.1.1.2 respiratory complex I
-
 Bos taurus
7.1.1.2 respiratory complex I
-
 Yarrowia lipolytica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.1.1.2 30
-
 assay at Paracoccus denitrificans
7.1.1.2 30
-
 assay at Bos taurus
7.1.1.2 30
-
 assay at Yarrowia lipolytica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1.1.2 8
-
 assay at Paracoccus denitrificans
7.1.1.2 8
-
 assay at Bos taurus
7.1.1.2 8
-
 assay at Yarrowia lipolytica

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Paracoccus denitrificans
7.1.1.2 NADH
-
 Bos taurus
7.1.1.2 NADH
-
 Yarrowia lipolytica

General Information

EC Number General Information Comment Organism
7.1.1.2 additional information the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site Paracoccus denitrificans
7.1.1.2 additional information the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site Yarrowia lipolytica
7.1.1.2 additional information the accessory’ subunits of eukaryotic complex I bear an allosteric ATP binding site Bos taurus