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Literature summary extracted from

  • Guirimand, G.; Guihur, A.; Ginis, O.; Poutrain, P.; Hericourt, F.; Oudin, A.; Lanoue, A.; St-Pierre, B.; Burlat, V.; Courdavault, V.
    The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites (2011), FEBS J., 278, 749-763.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.62 expression of SLS-GFP fusion protein in Catharanthus roseus cells show localization to the endoplasmic reticulum membranes Catharanthus roseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.62 endoplasmic reticulum the enzyme is anchored to the endoplasmic reticulum via a N-teminal helix, thus allowing the production of secologanin on the cytosolic side of the endoplasmic reticulum membrane Catharanthus roseus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.62 loganin + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.62 Catharanthus roseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.62 epidermis epidermis-specific expression of SLS Catharanthus roseus
-
1.14.19.62 leaf
-
 Catharanthus roseus
-
1.14.19.62 additional information RT-PCR tissue expression analysis, overview Catharanthus roseus
-
1.14.19.62 seedling
-
 Catharanthus roseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.62 loganin + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.62 CYP71A1
-
 Catharanthus roseus
1.14.19.62 cytochrome P450 secologanin synthase
-
 Catharanthus roseus
1.14.19.62 SLS
-
 Catharanthus roseus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.62 cytochrome P450 CYP71A1 Catharanthus roseus

General Information

EC Number General Information Comment Organism
1.14.19.62 malfunction mutant DELTAthSLS fusion protein forms punctuated aggregates in the cytosol in close vicinity with plastids Catharanthus roseus
1.14.19.62 metabolism the enzyme catalyzes the last step of the monoterpene secoiridoid pathway Catharanthus roseus
1.14.19.62 additional information the enzyme is anchored to the endoplasmic reticulum via a N-teminal helix, thus allowing the production of secologanin on the cytosolic side of the endoplasmic reticulum membrane Catharanthus roseus