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Literature summary extracted from

  • Aldeco, M.; Arslan, B.K.; Edmondson, D.E.
    Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B (2011), Comp. Biochem. Physiol. B, 159, 78-83.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 expressed in Pichia pastoris Danio rerio

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 8-(3-chlorostyryl)-caffeine
-
 Danio rerio
1.4.3.4 D-amphetamine
-
 Danio rerio
1.4.3.4 Harmane
-
 Danio rerio
1.4.3.4 methylene blue
-
 Danio rerio
1.4.3.4 additional information not inhibited by D-amphetamine, farnesol, safinamide, 1,4-diphenyl-1,3-butadiene, and 1,4-diphenyl-2-butene Danio rerio
1.4.3.4 pirlindole mesylate
-
 Danio rerio
1.4.3.4 tetrindole mesylate
-
 Danio rerio

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.018
-
 tyramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.0555
-
 1-(4-methoxyphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.058
-
 kynuramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.0678
-
 1-(4-methylphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.069
-
 serotonin at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.076
-
 4-carboxybenzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.0822
-
 benzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.088
-
 dopamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.094
-
 1-(4-chlorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.103
-
 1-(4-bromophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.115
-
 1-[4-(trifluoromethyl)phenyl]methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.161
-
 1-(4-fluorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.185
-
 4-phenylbutylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.4 dopamine + H2O + O2 Danio rerio
-
 (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2 Danio rerio
-
 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2 Danio rerio
-
 (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2 Danio rerio
-
 (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Danio rerio
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 1-(4-bromophenyl)methanamine + H2O + O2
-
 Danio rerio 4-bromobenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 1-(4-chlorophenyl)methanamine + H2O + O2
-
 Danio rerio 4-chlorobenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 1-(4-fluorophenyl)methanamine + H2O + O2
-
 Danio rerio 4-fluorobenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 1-(4-methoxyphenyl)methanamine + H2O + O2
-
 Danio rerio 4-methoxybenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 1-(4-methylphenyl)methanamine + H2O + O2
-
 Danio rerio 4-methylbenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 1-[4-(trifluoromethyl)phenyl]methanamine + H2O + O2
-
 Danio rerio 4-(trifluoromethyl)benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 4-carboxybenzylamine + H2O + O2
-
 Danio rerio ?
-
 ?
1.4.3.4 4-phenylbutylamine + H2O + O2
-
 Danio rerio ?
-
 ?
1.4.3.4 benzylamine + H2O + O2
-
 Danio rerio benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 dopamine + H2O + O2
-
 Danio rerio (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2
-
 Danio rerio 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 additional information 3-aminomethylpyridine is not a substrate Danio rerio ?
-
 ?
1.4.3.4 serotonin + H2O + O2
-
 Danio rerio (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2
-
 Danio rerio (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO
-
 Danio rerio

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.4 0.08
-
 benzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.088
-
 4-carboxybenzylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.12
-
 1-(4-methylphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.14
-
 1-(4-methoxyphenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.25
-
 1-(4-fluorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.58
-
 1-(4-chlorophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.67
-
 1-(4-bromophenyl)methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 1.25
-
 kynuramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 1.57
-
 1-[4-(trifluoromethyl)phenyl]methanamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 2.07
-
 4-phenylbutylamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 3.12
-
 serotonin at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 4.03
-
 dopamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 7.78
-
 tyramine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 FAD
-
 Danio rerio

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.000004
-
 methylene blue at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.0024
-
 pirlindole mesylate at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.0024
-
 8-(3-chlorostyryl)-caffeine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.013
-
 Harmane at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.0341
-
 tetrindole mesylate at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio
1.4.3.4 0.038
-
 D-amphetamine at 25°C in 50 mM potassium phosphate, pH 7.4 Danio rerio