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Literature summary extracted from

  • Funabashi, M.; Baba, S.; Nonaka, K.; Hosobuchi, M.; Fujita, Y.; Shibata, T.; Van Lanen, S.G.
    The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase (2010), Chembiochem, 11, 184-190.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.B5 expression in Escherichia coli Streptomyces sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.B5 an aryl sulfate + desulfo-A-90289A Streptomyces sp. LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins a phenol + A-90289A
-
 ?
2.8.2.B5 an aryl sulfate + desulfo-A-90289A Streptomyces sp. SANK 60405 LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins a phenol + A-90289A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.B5 Streptomyces sp. D4QF15
-
-
2.8.2.B5 Streptomyces sp. SANK 60405 D4QF15
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.B5 recombinant enzyme Streptomyces sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.B5 4-nitrophenyl sulfate + desulfo-A-90289A sulfate transfer occurs at the 2’-hydroxyl. The enzyme shows no activity with 3'-phosphoadenylyl sulfate Streptomyces sp. 4-nitrophenol + A-90289A
-
 ?
2.8.2.B5 4-nitrophenyl sulfate + desulfo-A-90289A sulfate transfer occurs at the 2’-hydroxyl. The enzyme shows no activity with 3'-phosphoadenylyl sulfate Streptomyces sp. SANK 60405 4-nitrophenol + A-90289A
-
 ?
2.8.2.B5 an aryl sulfate + desulfo-A-90289A LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins Streptomyces sp. a phenol + A-90289A
-
 ?
2.8.2.B5 an aryl sulfate + desulfo-A-90289A LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins Streptomyces sp. SANK 60405 a phenol + A-90289A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.B5 LipB ambiguous Streptomyces sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.B5 30
-
 assay at Streptomyces sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.B5 8
-
 assay at Streptomyces sp.

General Information

EC Number General Information Comment Organism
2.8.2.B5 malfunction the DELTALipB mutant strain produces desulfo-A-90289s Streptomyces sp.
2.8.2.B5 physiological function LipB is a sulfotransferase involved in A-90289 biosynthesis. Sulfate incorporation by LipB might represent a self resistance strategy that leads to inactivation of the antibiotic A-90289s and lipsodiomycins Streptomyces sp.